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http://dx.doi.org/10.1038/s41392-023-01534-0 | DOI Listing |
Org Lett
September 2025
State Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China.
Optically active α-aminophosphonic acids are unique analogues of α-amino acids, and numerous synthetic methods have been developed. Herein, we present a highly diastereoselective α-azidation approach to the CAMDOL-derived phosphonates, enabling ready access to 27 diverse α-azidophosphonates with defined chirality in up to 85% yield and more than 99:1 dr. Late-stage transformations through the Staudinger reaction or click reaction efficiently delivered the related pharmacological α-aminophosphonic acids or the unique α-triazolylphosphonate derivative, respectively.
View Article and Find Full Text PDFInt J Surg
September 2025
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Objectives: To provide a bibliometric overview of the global research on the therapeutic applications of the suprachoroidal space (SCS) from 2000 to 2024.
Methods: Publications were retrieved from the Web of Science Core Collection using a defined search strategy. A total of 776 articles were analyzed for trends in publication volume, countries, institutions, authorship, journals, citations, and keywords.
Front Genet
August 2025
Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, TN, United States.
Research carried out by Vanderbilt University's and Medical Center's federally-funded transdisciplinary, highly interactive GetPreCiSe Center in Excellence for ELSI research on genomic privacy-involving over 40 scholars across computer and social sciences, law, and the humanities-is summarized by dividing the work into five categories: (1) the nature of risks posed by collection of genetic data; (2) legal and scientific methods of minimizing those risks; (3) methods of safely increasing the scope of genetic databases; (4) public perceptions of genetic privacy; and (5) cultural depictions of genetic privacy. While this research shows that the risk of unauthorized re-identification is often over-stated, it also identifies possible ways privacy can be compromised. Several technical and legal methods for reducing privacy risks are described, most of which focus not on collection of the data, but rather on regulating data security, access, and use once it is collected.
View Article and Find Full Text PDFCureus
August 2025
Department of Oncology, University of Warmia and Mazury in Olsztyn, Olsztyn, POL.
Management of recurrent adenoid cystic carcinoma (ACC) in elderly patients remains challenging due to comorbidities, functional impairments, and anatomically complex tumor locations that complicate surgical access and increase operative risk. The ZAP-X Gyroscopic Radiosurgery System (ZAP Surgical Systems, Inc., San Carlos, CA, USA) offers a highly precise, non-invasive treatment modality, potentially suitable for salvage therapy in previously irradiated fields and in medically inoperable patients.
View Article and Find Full Text PDFFront Bioeng Biotechnol
August 2025
Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Electroactive polymer (EAP) artificial muscles are gaining attention in robotic control technologies. Among them, the development of self-sensing actuators that integrate sensing mechanisms within artificial muscles is highly anticipated. This study aimed to evaluate the accuracy and precision of the sensing capabilities of the e-Rubber (eR), an artificial muscle developed by Toyoda Gosei Co.
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