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Renal cell carcinoma (RCC) exhibits a propensity for unusual wide metastasis. Cutaneous metastasis from RCC is a rare and poorly recognized clinical entity. We present a case of cutaneous metastasis of poorly differentiated RCC in 49-year-old male patient. In the presented case, the skin lesion was the first sign of widely spread RCC. After the establishment of the diagnosis using radiological and histopathological assessments, the patient was labeled as a terminal case and was referred for pain management. He deceased after 6 months of the initial presentation.
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http://dx.doi.org/10.1016/j.eucr.2023.102430 | DOI Listing |
J Am Acad Dermatol
September 2025
Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine.
Front Immunol
September 2025
Wound Healing Center, Peking University Third Hospital, Beijing, China.
Background And Objective: Melanoma exhibits profound biological complexity, driven by immune evasion, phenotypic plasticity, and resistance to therapy. While programmed cell death (PCD) shapes tumor-immune interactions, its mechanistic landscape in melanoma remains incompletely defined. This study aims to comprehensively characterize PCD-related signatures and their associations with tumor heterogeneity, prognosis, and immunotherapeutic outcomes.
View Article and Find Full Text PDFJ Dermatol
September 2025
Department of Dermatology, Graduate School of Medicine, University of the Ryukyus, Ginowan, Japan.
Brain metastasis from cutaneous angiosarcoma of the scalp is rare, and the characteristics and optimal treatment remain poorly understood. Herein, we report three cases of brain metastasis originating from cAS of the scalp. Case 1: An 81-year-old male developed lung metastasis 2.
View Article and Find Full Text PDFJ Cutan Pathol
September 2025
Department of Dermatology and Pathology, University of California, Irvine, Irvine, California, USA.
Primary cutaneous apocrine carcinoma (PCAC) is an exceptionally rare cutaneous malignancy originating from apocrine glands, occurring most commonly in the axilla and anogenital regions. It typically follows a slow-growing clinical course, although aggressive behavior has been documented in select cases. While local recurrence and regional metastasis are not uncommon in PCAC, instances of distant metastases are rare, with only a handful of cases reported, including involvement of the liver, bone, and lung.
View Article and Find Full Text PDFJ Cell Mol Med
September 2025
Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Protein S-palmitoylation, a dynamic and reversible post-translational modification involving the attachment of palmitate to cysteine residues, is a key regulator of protein functionality and cellular signalling. Dysregulation of this modification has emerged as a critical driver of cancer progression. Among the 23 DHHC palmitoyl transferases responsible for catalysing S-palmitoylation, aberrant expression of specific members is linked to tumorigenesis and development, underscoring their potential as promising therapeutic targets.
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