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A case of primary synovial sarcoma of the jejunum was collected and analyzed retrospectively. A 19-year-old man who presented to hospital with abdominal pain. The CT scan showed a large mixed abdominal mass with bleeding. Laparotomy revealed that the tumor originated from the jejunum, accompanied by rupture and hemorrhage. Microscopically, the tumor was composed of spindle cells. The tumor cells demonstrated diffuse expression of vimentin, transducin-like enhancer (TLE)-1, B-cell lymphoma protein (Bcl)-2, CD99 and focal expression of epithelial membrane antigen (EMA). The presence of specific gene rearrangement was confirmed in tumor cells. The patient received 6 cycles of chemotherapy after jejunal tumor resection. And 12 months later, the patient presented pancreatic metastasis and had radiotherapy. The patient died 15 months after the diagnosis.
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http://dx.doi.org/10.3724/zdxbyxb-2022-0117 | DOI Listing |
Front Oncol
August 2025
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Synovial sarcoma (SS) is one of the most prevalent malignant soft tissue sarcomas in children and adolescents. Pediatric populations often present with atypical features, complicating the differentiation from benign intramuscular venous malformations (VMs).
case Presentation: An 11-year-old male with a four-year history of progressive right plantar pain and a compressible intramuscular mass.
Case Rep Pathol
September 2025
Faculty of Medicine, KCMC University, Moshi, Tanzania.
Synovial sarcomas are rare malignant soft tissue tumors with significant metastatic potential. Although they can occur in various parts of the body, they are most commonly found on the extremities. These tumors typically develop in children and young adults, making occurrences in individuals over 50 years of age unusual.
View Article and Find Full Text PDFBackground: Sarcomas of the trunk and abdominal wall are rare and present unique challenges in both resection with free margins and reconstruction, particularly when the tissue loss is extensive. These tumors predominantly affect young, active individuals, posing a significant challenge for oncologists and plastic surgeons in preserving the patients' quality of life.
Case Presentation: We present the case of 23-year-old woman with no significant medical history.
Oncogene
August 2025
Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
The SS18::SSX oncogene is the driver of synovial sarcoma, an aggressive cancer presenting in young adults that has poor long-term outcomes. Over the past five years, significant progress has been made in understanding the molecular, genomic, and epigenetic mechanisms underlying synovial sarcoma. This review synthesizes recent advancements in synovial sarcoma, including diagnostic pathology, genomic profiling, SS18::SSX biology, epigenetic dysregulation, proteomics, targetable pathways and immunotherapy.
View Article and Find Full Text PDFJ Clin Pathol
August 2025
Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Aims: To investigate immunohistochemical expression of the E26 transformation-specific factors (ETS)-related gene () in a large number of soft tissue neoplasms using a tissue microarray technique.
Methods: 489 cases of soft tissue neoplasms, including benign and malignant entities, were collected from the files of the respective institutions and constructed into tissue microarrays. Tissue microarrays were stained for ERG immunohistochemistry using two antibodies, EP111 and EPR3864.