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One chromone (), together with four known alkaloids, were isolated from the mangrove endophytic fungus sp. ZJ-68. Their structures were elucidated by a combination of HRESIMS and NMR spectroscopic analyses. Compound showed strong anti-inflammatory activity by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 cells with an IC value of 4.094 ± 0.8 μM, which was better than positive drug indomethacin (IC=35.8 ± 0.5 μM).
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http://dx.doi.org/10.1080/10286020.2023.2197226 | DOI Listing |
Front Microbiol
August 2025
College of Veterinary Medicine, Northwest A&F University, Xianyang, Shaanxi, China.
Locoism refers to a neurological disorder in livestock caused by chronic ingestion of locoweeds, which contain toxic alkaloid swainsonine produced by the fungus . Therefore, reducing swainsonine levels not only prevents locoism but may also transform these toxic plants into animal feed. In this study, we identified a pivotal role for the gene in swainsonine biosynthesis.
View Article and Find Full Text PDFMicrob Cell Fact
September 2025
Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31257, Egypt.
Background And Aim: Synthetic dyes in the textile industry pose risks to human health and environmental safety. The current study aims to examine the efficacy of a novel esterase derived from an endophyte fungus in decolorizing diverse dyes, focusing on its production, purification, optimization, and characterization.
Results: Trichoderma afroharzianum AUMC16433, a novel fungal endophyte with esterase-producing ability, was first detected from the cladodes of Opuntia ficus indica by ITS-rRNA sequencing.
Appl Microbiol Biotechnol
September 2025
School of Plant Sciences, The University of Arizona, 1140 E South Campus Drive, Forbes 303, Tucson, AZ, 85721, USA.
Fungal endophytes and epiphytes associated with plant leaves can play important ecological roles through the production of specialized metabolites encoded by biosynthetic gene clusters (BGCs). However, their functional capacity, especially in crops like lettuce (Lactuca sativa L.), remains poorly understood.
View Article and Find Full Text PDFCurr Genet
September 2025
Fermentation and Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, 180001, India.
Trichoderma species exhibit remarkable versatility in adaptability and in occupying habitats with lifestyles ranging from mycoparasitism and saprotrophy to endophytism. In this study, we present the first high-quality whole-genome assembly and annotation of T. lixii using Illumina HiSeq technology to explore the mechanisms of endophytic lifestyle and plant colonization.
View Article and Find Full Text PDFChem Biodivers
September 2025
Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, India.
Argemone mexicana is one of the known herbaceous plants hosting bioactive isoquinoline alkaloids. In the current study, an endophytic fungal isolate was studied for anti-inflammatory potential and the identification of its bioactive molecule. An endophytic fungus AMEF-14 was obtained from this plant and identified as Cladosporium ramotenellum based on microscopy and molecular tools.
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