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Article Abstract
To develop quercetin nanocrystals by a simple approach and to evaluate their antifibrotic efficacy. Nanosuspensions were fabricated by a thin-film hydration technique and ultrasonication. The influence of process variables on the average diameter of quercetin nanoparticles was investigated. Moreover, efficacy was investigated in an established murine CCl-induced fibrosis model. Nanocrystals showed a particle size of <400 nm. The optimized formulations showed an increase in dissolution rate and solubility. Quercetin nanocrystals markedly prevented fibrotic changes in the liver, as evidenced by mitigated histopathological changes and diminished aminotransferase levels and collagen accumulation. The findings reflect the promising potential of quercetin nanocrystals for liver fibrosis prevention.
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| http://dx.doi.org/10.2217/nnm-2022-0032 | DOI Listing |
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