Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The convenient and highly compliant route for the delivery of active pharmaceutical ingredients is the tablet. A versatile platform of tablets is available for the delivery of therapeutic agents to the gastrointestinal tract. This study aimed to prepare gastro retentive drug delivery floating tablets of silymarin to improve its oral bioavailability and solubility. Hydroxypropyl methylcellulose (HPMCK4M and HPMCK15), Carbopol 934p and sodium bicarbonate were used as a matrix, floating enhancer and gas generating agent, respectively. The prepared tablets were evaluated for physicochemical parameters such as hardness, weight variation, friability, floating properties (floating lag time, total floating time), drug content, stability study, in vitro drug release, in vivo floating behavior and in vivo pharmacokinetics. The drug-polymer interaction was studied by Differential Scanning Calorimetry (DSC) thermal analysis and Fourier transform infrared (FTIR). The floating lag time of the formulation was within the prescribed limit (<2 min). The formulation showed good matrix integrity and retarded the release of drug for >12 h. The dissolution can be described by zero-order kinetics (r = 0.979), with anomalous diffusion as the release mechanism ( = 0.65). An in vivo pharmacokinetic study showed that Cmax and AUC were increased by up to two times in comparison with the conventional dosage form. An in vivo imaging study showed that the tablet was present in the stomach for 12 h. It can be concluded from this study that the combined matrix system containing hydrophobic and hydrophilic polymers min imized the burst release of the drug from the tablet and achieved a drug release by zero-order kinetics, which is practically difficult with only a hydrophilic matrix. An in vivo pharmacokinetic study elaborated that the bioavailability and solubility of silymarin were improved with an increased mean residence time.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054735 | PMC |
| http://dx.doi.org/10.3390/molecules28062606 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A FLOATING ENDOMETRIAL ORGANOID MODEL RECAPITULATES EPITHELIAL-STROMAL CELL INTERACTIONS IN VITRO.
Exp Cell Res
September 2025
Section of Pharmacology, Department of Internal Medicine, University of Genova, 16132, Genova, Italy; IRCCS Ospedale Policlinico San Martino, 16132, Genova, Italy. Electronic address:
Organoids are 3D structures in which stem, progenitor and differentiated cells spontaneously assemble into structures resembling the original tissue. Endometrial organoids, developed from tissue fragments, are genetically stable and responsive to hormone stimulation acquiring a hallow lumen, secretory activity and apico-basal polarity. However, they show some limitations in mimicking the midluteal endometrium since they lack endothelial, immune, and stromal cells, thus providing limited information about epithelial-stromal interactions.
View Article and Find Full Text PDFBenchmarking AI-driven acoustic monitoring for floating marine debris: Challenges in deep learning-based debris extraction.
Mar Pollut Bull
September 2025
Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8563, Japan. Electronic address:
Existing studies have identified a substantial amount of invisible floating debris in low-visibility marine environments, in addition to debris on the surface and seabed. These suspended pollutants represent a persistent and dynamic threat to marine ecosystems and maritime safety. Although sonar technology facilitates debris monitoring in low-visibility waters, the automatic extraction of small and weakly contrasted debris targets remains a critical challenge.
View Article and Find Full Text PDFMitigating Fox Predation on Freshwater Turtle Nests: Comparing Effectiveness of Three In Situ Protection Methods.
Ecol Evol
September 2025
Department of Ecological, Plant & Animal Sciences Centre for Freshwater Ecosystems, School of Agriculture, Biomedicine and Environment, La Trobe University, Albury-Wodonga Campus West Wodonga Victoria Australia.
Freshwater turtles in the Murray-Darling Basin (MDB), Australia, have declined since the 1970s. Intense nest predation by introduced foxes likely contributes to these declines, disrupting juvenile recruitment needed to sustain populations. Traditional lethal control methods, such as baiting and shooting, have proven inadequate, highlighting the need for innovative conservation strategies.
View Article and Find Full Text PDFLate relapse of extranodal NK/T-cell lymphoma presenting as an adrenal mass with suspected cardiac involvement.
BMJ Case Rep
September 2025
Hematology/Oncology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA.
Extranodal natural killer/T-cell lymphoma (ENKTCL), nasal type, is a rare and aggressive subtype of non-Hodgkin's lymphoma that often presents with extranodal involvement. While relapse patterns commonly involve the nasal cavity, lungs or skin, cardiac involvement is rare. We report a late 50-year-old patient with ENKTCL, nasal type, who achieved complete remission following chemotherapy and autologous stem cell transplantation.
View Article and Find Full Text PDFLightweight rice leaf spot segmentation model based on improved DeepLabv3.
Front Plant Sci
August 2025
Faculty of Modern Agricultural Engineering, Kunming University of Science and Technology, Kunming, China.
Introduction: Rice is an important food crop but is susceptible to diseases. However, currently available spot segmentation models have high computational overhead and are difficult to deploy in field environments.
Methods: To address these limitations, a lightweight rice leaf spot segmentation model (MV3L-MSDE-PGFF-CA-DeepLabv3+, MMPC-DeepLabv3+) was developed for three common rice leaf diseases: rice blast, brown spot and bacterial leaf blight.