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Protein intake counteracts alcohol intake in the regulation of postprandial FGF21 secretion in humans.
Am J Physiol Endocrinol Metab
September 2025
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
FGF21 is a hormone secreted from the liver in response to various nutritional stressors, suggested to be acting to balance dietary intake through negative feedback regulation. This meal study aimed to investigate two different potential nutrient interactions on postprandial FGF21 secretion in healthy human participants: 1) between intake of alcohol and protein and 2) between intake of alcohol and vitamin A (retinol). In a 4-arm, randomized, double-blinded, cross-over meal study (NCT06105476), postprandial circulating concentrations of FGF21, glucose, insulin, ethanol, and acetate were compared after intake of four different test drinks containing alcohol, alcohol+protein, alcohol+retinol or retinol in 27 healthy humans.
View Article and Find Full Text PDFVitamin C Does Not Affect Platelet Counts in Patients With Sepsis: A Post hoc Analysis of the Lessening Organ Dysfunction With Vitamin C Randomized Trial.
Crit Care Explor
September 2025
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Objective: Vitamin C has been linked to alterations in platelet count and aggregation behavior. Given recent findings suggesting an association between vitamin C and adverse outcomes in patients with septic shock, we aimed to investigate whether vitamin C influences mortality in septic patients through its impact on platelets.
Design: Post hoc analysis of the Lessening Organ Dysfunction With Vitamin C (LOVIT) randomized trial (clinicaltrials.
Association of cord blood vitamin D and genetic polymorphisms with childhood food allergy in Shanghai, China: a prospective cohort.
Front Nutr
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Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai, China.
Background: Emerging evidence suggests vitamin D plays a dual role in immune regulation, yet its interplay with genetic susceptibility in early-life allergy development remains poorly understood. This prospective cohort study investigated whether cord blood 25-hydroxyvitamin D [25(OH)D] levels interact with immunoregulatory gene variants to influence childhood food allergy risk.
Methods: A total of 1,049 mother-infant pairs from the Shanghai Allergy Cohort were stratified by cord blood 25(OH)D concentrations (<15, 15-25, >25 ng/mL).
Intranasal zinc and vitamin A treatments alter response to bovine respiratory syncytial virus and co-infection.
Transl Anim Sci
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Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USA.
During disease, there may be increased local demands for zinc (Zn) and vitamin A to support pathogen response. This study evaluates the effects of intranasal Zn and vitamin A treatments on steers experimentally infected with bovine respiratory disease (BRD) pathogens, bovine respiratory syncytial virus (BRSV) and , hypothesizing that steers treated with Zn and vitamin A (VA) will have improved recovery to BRD challenge. Forty-eight Angus crossbred steers (333 ± 4.
View Article and Find Full Text PDFThe association between the MIND-NL diet, Dutch dietary guidelines, and global cognitive function in an older population at risk for cognitive decline.
J Nutr Health Aging
September 2025
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands. Electronic address:
Objectives: This study examined the association between adherence to the Dutch MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay, MIND-NL) and the Dutch dietary guidelines (DHD2015-index) with global cognitive function in older adults at risk of cognitive decline.
Design And Setting: A cross-sectional study was conducted using baseline data of the FINGER-NL trial.
Participants: A total of 1,135 older adults, aged 60-80 years, at risk for cognitive decline with complete dietary data and complete neuropsychological tests were included in the analyses.