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http://dx.doi.org/10.1016/j.healthpol.2023.104721 | DOI Listing |
J Pept Sci
October 2025
Institute of Technology, University of Tartu, Tartu, Estonia.
The development of therapeutic small interfering RNAs (siRNAs) has lately gained significant momentum due to their ability to silence genes in a highly specific manner. The main obstacle withholding the wider translation of siRNA-based drug modalities is their limited half-life and poor bioavailability, especially in extra-hepatic tissues. Consequently, various drug delivery systems (DDSs) have been developed to improve the delivery of siRNAs, including short delivery peptides called cell-penetrating peptides (CPPs).
View Article and Find Full Text PDFEnviron Res
September 2025
School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:
Introduction: Epidemiological studies focusing on the association of exposure to perfluoroalkyl substances (PFAS) with cardiovascular disease (CVD) morbidity and mortality are limited, with inconsistent findings.
Objectives: This register-based study aimed to investigate the associations between exposure to PFAS and the risk of CVD morbidity and mortality in a Swedish population exposed to PFAS, dominated by perfluorohexane sulfonic acid (PFHxS) and perfluorooctane sulfonic acid (PFOS), through drinking water for decades.
Methods: The study included 46 553 individuals aged ≥30 who lived in Ronneby (1985-2013).
Life Sci
September 2025
Department of Experimental Medical Science, Faculty of Medicine, Lund University, 221 84, Lund, Sweden; Wallenberg Center for Molecular Medicine, Faculty of Medicine, Lund University, 221 84, Lund, Sweden. Electronic address:
Aims: Experimental evidence suggests an important role for sphingosine-1-phosphate (S1P) and its generating enzymes sphingosine kinase 1/2 (SphK1/2) in obesity. We and others have shown that plasma S1P levels are elevated in obese mice and humans. Preclinical studies suggest that genetic SphK2 ablation in mice protects from age- and diet-induced obesity and metabolic dysfunction.
View Article and Find Full Text PDFPsychiatry Res
September 2025
Department of Clinical Sciences, Psychiatry, Lund University, Sölvegatan 19 - BMC I12, 221 84 Lund, Sweden. Electronic address:
Negative consequences of gambling problems have primarily been examined in terms of symptoms and impairment, with less focus on well-being, a key indicator of intra- and interpersonal functioning and a critical outcome in treatment. Additionally, the role of co-occurring psychopathology in this relation remains unclear. This study examined the relation between gambling problems and well-being in a large population-based sample of individuals who gamble (N = 1005; 52.
View Article and Find Full Text PDFSoc Psychiatry Psychiatr Epidemiol
September 2025
Department of Psychology, Harvard University, Cambridge, MA, USA.
Purpose: Hatzenbuehler's psychological mediation framework proposes that difficulties in emotion regulation (ER), which are driven in part by excess exposure to stigma-related experiences, contribute to sexual orientation-related mental health disparities. However, existing research on the framework has largely focused on a small number of ER variables in non-probability samples.
Methods: To address these limitations, we examined whether a large complement of ER components mediates the prospective association between sexual minority status and depressive symptoms, using longitudinal data from a population-based sample of 1,208 Swedish young adults (aged 18-35).