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Metabolic syndrome (Mets) is a clinical condition characterized by a cluster of major risk factors for cardiovascular disease (CVD) and type 2 diabetes: proatherogenic dyslipidemia, elevated blood pressure, dysglycemia, and abdominal obesity. Each risk factor has an independent effect, but, when aggregated, they become synergistic, doubling the risk of developing cardiovascular diseases and causing a 1.5-fold increase in all-cause mortality. We will highlight gender differences in the epidemiology, etiology, pathophysiology, and clinical expression of the aforementioned Mets components. Moreover, we will discuss gender differences in new biochemical markers of metabolic syndrome and cardiovascular risk.
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http://dx.doi.org/10.3390/ijms24021588 | DOI Listing |
J Med Internet Res
September 2025
Department of Psychological and Brain Sciences, Boston University, Boston, United States.
Background: Lesbian, gay, bisexual, transgender, queer/questioning, intersex, asexual (LGBTQIA+) researchers and participants frequently encounter hostility in virtual environments, particularly on social media platforms where public commentary on research advertisements can foster stigmatization. Despite a growing body of work on researcher virtual hostility, little empirical research has examined the actual content and emotional tone of public responses to LGBTQIA+-focused research recruitment.
Objective: This study aimed to analyze the thematic patterns and sentiment of social media comments directed at LGBTQIA+ research recruitment advertisements, in order to better understand how virtual stigma is communicated and how it may impact both researchers and potential participants.
PLoS One
September 2025
School of Law, Society and Criminology, UNSW, Sydney, New South Wales, Australia.
In this paper we analyse gender-based biases in the language within complex legal judgments. Our aims are: (i) to determine the extent to which purported biases discussed in the literature by feminist legal scholars are identifiable from the language of legal judgments themselves, and (ii) to uncover new forms of bias represented in the data that may promote further analysis and interpretation of the functioning of the legal system. We consider a large set of 2530 judgments in family law in Australia over a 20 year period, examining the way that male and female parties to a case are spoken to and about, by male and female judges, in relation to their capacity to provide care for children subject to the decision.
View Article and Find Full Text PDFPLoS One
September 2025
Center for Studies of Education and Psychology of Ethnic Minorities in Southwest China, Southwest University, Chongqing, China.
Background: Educational hypogamy, where women marry men with lower educational attainment, reflects evolving gender roles and societal norms. In China, the rapid expansion of education, coupled with persistent traditional values, provides a unique context to study this phenomenon.
Methods: Using data from the 2013, 2015, 2017, 2018, and 2021 waves of the China General Social Survey (CGSS), this study applies logistic regression models and Random Forest machine learning techniques to analyze the impact of education on women's selection of hypogamy.
PLoS One
September 2025
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
Background: Head and neck cancer (HNC) is a significant global health concern with rising incidence and mortality in certain regions. This study aimed to evaluate the global burden and temporal trends of HNC from 1990 to 2021 and to project its future burden through 2030.
Methods: Data were obtained from the Global Burden of Disease (GBD) 2021 study.
JAMA Intern Med
September 2025
Bayer CC AG, Basel, Switzerland.
Importance: There is an unmet need for long-term, safe, effective, and hormone-free treatments for menopausal symptoms, including vasomotor symptoms (VMS) and sleep disturbances.
Objective: To evaluate the 52-week efficacy and safety of elinzanetant, a dual neurokinin-targeted therapy, for treating moderate to severe VMS associated with menopause.
Design, Setting, And Participants: OASIS-3 was a double-blind, placebo-controlled, randomized phase 3 clinical trial that was conducted at 83 sites in North America and Europe from August 27, 2021, to February 12, 2024, and included postmenopausal women aged 40 to 65 years who were seeking treatment for moderate to severe VMS (no requirement for a minimum number of VMS events per week).