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The global covid-19 pandemic has imposed radical changes in daily lives. This study reflects upon sociodemographic and clinical characteristics (sleep-wake rhythm, psychiatric symptoms, and alcohol use behavior) during the full lockdown, comparing individuals who increased their alcohol use (iAU), those who maintained a stable use (sAU), and those who did not consume alcohol (AnoU). Participants were recruited via e-mails and they were required to complete an online survey that included questionnaires, during the last week of the full lockdown. The iAU group, compared to the sAU group, presented more disturbed sleep (PSQI; < .001), more severe insomnia (ISI; < .001), shorter sleep duration ( < .001), longer sleep latency ( < .001), and less regular sleep-wake schedules ( = .005). They also reported more anxiety (HAD-A; = .009), more depressive symptoms (HAD-D: = .006) and more psychotraumatic symptoms (PCL-5: = .018). Moreover, the sAU group, compared to AnoU, showed better quality of sleep (PSQI; = .002) and less severe anxiety symptoms (HAD-A; = .014). Maintaining a stable use was also related to a better quality of life associated with bigger homes with more frequent outdoors living spaces and higher monthly incomes. Individuals who increased their alcohol consumption during the Covid-19 lockdown exhibited more sleep and circadian rhythm disturbances, as well as more (severe) psychiatric symptoms.
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http://dx.doi.org/10.1080/07420528.2023.2168199 | DOI Listing |
Health Sci Rep
September 2025
Background And Aim: The circadian rhythm regulates various physiological processes, including sleep-wake cycle, cell division and cancer development. This study aimed to investigate circadian rhythm patterns in cancer patients.
Methods: In this cross-sectional study, 150 cancer patients admitted to the hospital enrolled the study during the fall of 2022.
J Pediatr (Rio J)
September 2025
Escola de Medicina da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil; Instituto do Cérebro (InsCer), Porto Alegre, RS, Brazil. Electronic address:
Objective: To review the associations between various neurodevelopmental disorders and the most prevalent sleep disorders in children and adolescents, focusing on clinical characteristics and diagnostic approaches.
Data Sources: A literature review was conducted using the PubMed database, employing the search terms "neurodevelopmental disorders" and "sleep disorders," including "insomnia," "sleep-related breathing disorders," "circadian rhythm sleep-wake disorders," "sleep-related movement disorders," "parasomnias," and "central disorders of hypersomnolence." Specific diagnostic terms related to neurodevelopmental and sleep disorders were also utilized.
R Soc Open Sci
September 2025
Department of Biology, University of Antwerp, Antwerp, Belgium.
Circadian clocks play a crucial role in regulating the sleep-wake rhythm of organisms, aligning their activity with fluctuating environmental factors, such as light intensity. Still, significant and consistent interindividual differences in the timing of activity, known as chronotypes, have been observed across various species, but whether this affects fitness is still unknown. While previous studies have primarily focused on annual reproductive success, few studies have examined associations between chronotype and lifetime reproductive success.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Sleep disorders, such as insomnia, sleep terrors, sleep apnea, and sleep-wake schedule disorders, pose a significant public health challenge worldwide, yet their underlying pathophysiological mechanisms are not fully understood. Lipids, beyond being structural membrane components, actively regulate neuroinflammation, circadian rhythms, and neuronal signaling, all implicated in sleep disorder pathophysiology. This study employed two-sample Mendelian randomization (TSMR) to explore the causal relationships between the lipidome and these sleep disorders, analyzing a comprehensive GWAS dataset with 179 lipid species.
View Article and Find Full Text PDFJ Neuroendocrinol
August 2025
University of Strasbourg, INSERM, UMR-S 1329, Strasbourg Translational Neuroscience & Psychiatry, Strasbourg, France.
Sleep and circadian rest-activity rhythm alterations are recognised as inherent clinical features of various neurodegenerative diseases. Traditionally viewed as secondary manifestations of neurodegeneration, recent studies have revealed that disruptions in circadian rhythm and sleep-wake cycles can precede clinical symptoms and significantly contribute to the underlying pathophysiological progression. In this review, we summarise recent research on the impact of sleep and circadian rhythm alterations in ageing and major neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and frontotemporal dementia, highlighting the roles of melatonin, orexin, and melanin-concentrating hormone (MCH) systems as key regulators at the intersection of sleep and neurodegeneration.
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