Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: Invasive lobular breast cancer (ILC) may be hard to detect using conventional imaging modalities and usually shows less avidity to 18 F-FDG PET/CT. 68 Ga-fibroblast activation protein inhibitor (FAPI) PET/CT has shown promising results in detecting non- 18 F-FDG-avid cancers. We aimed to assess the feasibility of detecting metastatic disease in patients with non- 18 F-FDG-avid ILC.
Methods: This prospective study included patients with metastatic ILC, infiltrative to soft tissues, which was not 18 F-FDG avid. The patients underwent 68 Ga-FAPI PET/CT for evaluation, which was correlated with the fully diagnostic CT performed at the same time.
Results: Seven women (aged 57 ± 10 years) were included. Among the 30 organs and structures found to be involved by tumor, the number of findings observed by FAPI PET/CT was significantly higher than that observed by CT alone ( P = 0.022), especially in infiltrative soft tissue and serosal locations.
Conclusions: This small pilot trial suggests a role for 68 Ga-FAPI PET/CT in ILC, which needs to be confirmed by subsequent trials.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/RLU.0000000000004540 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
PET/CT in breast cancer.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
September 2025
Servicio de Medicina Nuclear, Clínica Universidad de Navarra, Madrid, Spain; Grupo de Trabajo de Oncología de la SEMNIM, Spain.
Breast cancer is one of the most prevalent neoplasms worldwide, with molecular subtypes that influence prognosis and therapeutic strategies. PET/CT with different radiopharmaceuticals has revolutionized diagnosis, staging, and treatment monitoring. [F]-Fluorodeoxyglucose remains the most widely used radiotracer, but it has limitations in certain subtypes, such as invasive lobular carcinoma, where 16α-[F] fluoro-17β-estradiol and [Ga]-FAPI (fibroblast activation protein inhibitors) have demonstrated greater utility.
View Article and Find Full Text PDFComparison of [Ga]Ga-FAPI-04 and [F]FDG PET/CT for detection of bone metastases of lung cancer.
Quant Imaging Med Surg
September 2025
Department of Nuclear Medicine, Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences (Sichuan Second Hospital of Traditional Chinese Medicine), Chengdu, China.
Background: Bone metastases of lung cancer typically indicate disease progression and poor prognosis. Early and accurate detection is crucial for staging, treatment planning, and prognostic evaluation. This study aimed to compare the diagnostic value of gallium 68-labeled fibroblast-activation protein inhibitor-04 ([Ga]Ga-FAPI-04) and fluorine 18-labeled fluorodeoxyglucose ([F]FDG) positron-emission tomography/computed tomography (PET/CT) imaging in detecting bone metastases in lung cancer.
View Article and Find Full Text PDFUltrafast Multi-tracer Total-body PET Imaging Using a Transformer-Based Deep Learning Model.
Acad Radiol
August 2025
Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, CH‑1211 Geneva, Switzerland (H.S., A.S., Y.S., C.E.D., C.I., H.Z.); Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands
Background: Reducing PET scan acquisition time to minimize motion-related artifacts and improving patient comfort is always demanding. This study proposes a deep-learning framework for synthesizing diagnostic-quality PET images from ultrafast scans in multi-tracer total-body PET imaging.
Methods: A retrospective analysis was conducted on clinical uEXPLORER PET/CT datasets from a single institution, including [F]FDG (N=50), [F]FAPI (N=45) and [Ga]FAPI (N=60) studies.
Fibroblast activation protein expression in the tumor microenvironment is crucial in survival prediction and differentiation of recurrent gliomas: a head-to-head comparison of Ga-FAPI-04 and F-FET in PET/CT imaging.
EJNMMI Radiopharm Chem
August 2025
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Background: The precise differentiation of recurrent glioma from treatment-related changes, such as pseudoprogression or radiation necrosis, is essential for treatment planning and remains a significant challenge. Fibroblast activation protein (FAP) expressed by cancer-associated fibroblasts can be targeted with PET tracers for in vivo visualization and quantification. This study aims to evaluate the diagnostic and prognostic effectiveness of FAP expression in patients with potential recurrent glioma by directly comparing [gallium-68] FAP inhibitor-04 and [fluorine-18] fluoroethyl-L-tyrosine PET/CT imaging.
View Article and Find Full Text PDFAdvancements in the non-invasive diagnosis of renal fibrosis.
Front Med (Lausanne)
July 2025
Department of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Renal fibrosis is the central pathological pathway by which various primary and secondary kidney diseases progress to end-stage renal disease. It is characterized by excessive extracellular matrix deposition and destruction of the native renal parenchyma, ultimately leading to irreversible loss of nephrons. Currently, percutaneous renal biopsy with histopathological evaluation remains the diagnostic gold standard for renal fibrosis, allowing semiquantitative scoring of renal interstitial fibrosis and glomerulosclerosis (e.
View Article and Find Full Text PDF