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Article Abstract
The rat lungworm is globally known to be the cause of oeosinophilic meningitis in humans. Another congener, , is closely related to and has been described as a potential human pathogenic parasite. These 2 worms are similar in terms of life cycle, host range and morphological and genetic information. However, there are limited studies about their genetic diversity based on the 66-kDa protein-encoding gene. The objective of this study was to explore the 66-kDa protein sequence variation of and collected from Thailand. Two adult and 53 third-stage larval specimens of from 4 geographic locations in Thailand were molecularly identified using the 66-kDa protein gene. The phylogenetic trees (Bayesian inference tree and maximum-likelihood tree) showed that formed a monophyletic clade with a clear separation between and . The genetic distance between and varies from 0.82 to 2.86%, with a total of 16 variable sites. The analysis of genetic diversity revealed 1 and 5 new haplotypes of and , respectively, and showed genetic differences between the populations of and . The haplotype networks of and populations in Thailand are similar to those of populations in some countries, indicating the range expansion of genomic origin between populations in different areas. In conclusion, the 66-kDa protein gene was a good genetic marker for studying genetic diversity and discriminating between and .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090599 | PMC |
| http://dx.doi.org/10.1017/S0031182022001573 | DOI Listing |
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