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A statistic often quoted is that <15% of research is translated into practice and routine adoption of novel research findings can take up to 17 years. Dissemination and implementation science is a field of research focused on studying and developing approaches that can increase the uptake of such innovations, thereby reducing the significant time lag between scientific discovery and widespread adoption. As such, it can have a major clinical impact by increasing the utilization of proven innovations in routine clinical practice using systematic frameworks to implement, disseminate, and evaluate the successful application of evidence-based practices. Herein, we discuss the background and theory of implementation science, major frameworks and considerations for study design, and current examples of its application in surgical research.
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http://dx.doi.org/10.1053/j.semvascsurg.2022.10.001 | DOI Listing |
PLoS One
September 2025
Department of Computer Science, COMSATS University Islamabad, Sahiwal, Pakistan.
The widespread dissemination of fake news presents a critical challenge to the integrity of digital information and erodes public trust. This urgent problem necessitates the development of sophisticated and reliable automated detection mechanisms. This study addresses this gap by proposing a robust fake news detection framework centred on a transformer-based architecture.
View Article and Find Full Text PDFPEC Innov
December 2025
Institute for General Practice and Palliative Care, Hannover Medical School, Germany.
Background: In healthcare education, virtual reality (VR), simulating real-world situations, is emerging as a tool to improve communication skills, particularly in sensitive scenarios involving patients and caregivers. While promising, VR-based education also poses challenges such as avatar realism, cognitive load, and the need for pedagogical grounding.
Objective: This protocol paper presents the VR-TALKS project, which aims to develop, apply, and evaluate VR scenarios designed to teach healthcare students communication skills in serious illness scenarios.
Biomaterials
September 2025
Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, 610041, PR China. Electronic address:
Host immune elimination largely limits the application of oncolytic viruses in clinics. Here, we rationally design a bioactive platelet-based oncolytic adenovirus delivery system. Upon loading adenoviruses, platelets are transformed to a pro-endocytosis status, which facilitates their internalization by circulating tumor cells (CTCs).
View Article and Find Full Text PDFBrief Bioinform
September 2025
Department of Computer Science, Hanyang University, 222 Wangsimni-ro, Seoul 04763, Republic of Korea.
Motivation: Mobile genetic elements (MGEs) play an important role in facilitating the acquisition of antibiotic resistance genes (ARGs) within microbial communities, significantly impacting the evolution of antibiotic resistance. Understanding the mechanism and trajectory of ARG acquisition requires a comprehensive analysis of the ARG-carrying mobilome-a collective set of MGEs carrying ARGs. However, identifying the mobilome within complex microbiomes poses considerable challenges.
View Article and Find Full Text PDFJ Hazard Mater
August 2025
School of Resources and Environment, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:
Residues of veterinary antibiotics such as tylosin in soils can induce selective pressure on indigenous soil microbes and increase the dissemination risk of antibiotic resistance genes (ARGs) by horizontal gene transfer (HGT), which poses a serious threat to both soil and public health. While conventional bioremediation methods face challenges in efficiency and stability, enzyme-based approaches offer promising alternatives. This study developed a novel biochar-immobilized tylosin-degrading enzyme (BIE) system to simultaneously address tylosin contamination and antibiotic resistance gene (ARG) proliferation in agricultural soils.
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