In-situ remediation efficiency and mechanism of tylosin contaminated soil with biochar immobilized degrading enzyme.

Residues of veterinary antibiotics such as tylosin in soils can induce selective pressure on indigenous soil microbes and increase the dissemination risk of antibiotic resistance genes (ARGs) by horizontal gene transfer (HGT), which poses a serious threat to both soil and public health. While conventional bioremediation methods face challenges in efficiency and stability, enzyme-based approaches offer promising alternatives. This study developed a novel biochar-immobilized tylosin-degrading enzyme (BIE) system to simultaneously address tylosin contamination and antibiotic resistance gene (ARG) proliferation in agricultural soils.

Integrative multi-omics analysis reveals novel therapeutic targets for glioblastoma.

Background And Objectives: Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, yet effective therapeutic strategies remain limited. A comprehensive exploration of brain proteomic profiles may offer new insights into GBM pathogenesis and treatment.

Methods: We integrated the largest available summary-level GWAS data for GBM, derived from eight studies of European ancestry, with brain proteomic and transcriptomic data.

Epigenetic age acceleration and rheumatoid arthritis: an NHANES-based analysis and survival prediction models.

Objective: Epigenetic aging has been confirmed to be associated with the pathogenesis of rheumatoid arthritis (RA), however, its role in the prognosis of RA remains unclear.

Methods: In this cross-sectional and prospective study, Epigenetic age and acceleration in participants of the National Health and Nutrition Examination Survey (NHANES) were calculated with Horvath's clock, Hannum's clock, PhenoAge, GrimAge, and GrimAge version 2 (GrimAge2). The association of epigenetic age and epigenetic age acceleration with the prevalence and overall mortality risk in RA was assessed with prediction models constructed.

SLAMF8 and NINJ2 promote neuroinflammation and oxidative stress through TLR4 NF kappa B pathway in Alzheimer's disease.

This study aimed to investigate the expression and role of Signaling Lymphocytic Activation Molecule Family Member 8 (SLAMF8) in Alzheimer's disease (AD), particularly its interaction with NINJ2 in the TLR4/NF-κB signaling pathway. SLAMF8 expression levels in AD models were analyzed using the Gene Expression Omnibus (GEO) database. Validation of SLAMF8 expression was conducted through RT-PCR and Western blot in Aβ-exposed SH-SY5Y cells, LPS-exposed HMC3 cells, and APP/PS1 transgenic mice.

Association between ketogenic diets and depression: A cross-sectional analysis of the NHANES 2005-2023 August.

Background: The ketogenic diet (KD) is widely used for epilepsy and neurodegenerative diseases. Glutamate, the excitatory neurotransmitter in the body, has been found to be significantly elevated in the brains of some patients with depression. Ketone bodies, the main products of KD, may negatively regulate the metabolic activity of glutamate, which suggests a potential role in the onset and progression of depression.

Research on Hydrogen Production from Ammonia Decomposition by Pulsed Plasma Catalysis.

Driven by dual-carbon targets, marine engines are accelerating their transition towards low-carbon and zero-carbon. Ammonium-hydrogen fusion fuel is considered to be one of the most promising fuels for ship decarbonization. Using non-thermal plasma (NTP) catalytic ammonia on-line hydrogen production technology to achieve hydrogen supply is one of the most important means to guarantee the safety and effectiveness of hydrogen energy in the storage and transportation process.

A comprehensive review of GPR84: A novel player in pathophysiology and treatment.

G protein-coupled receptor 84 (GPR84), a member of the highly conserved rhodopsin-like superfamily, represents a promising target for therapeutic drug development. Its distinctive expression profiles in adipocytes, gut endocrine cells, and various myeloid immune cells underscore its critical roles in fundamental physiological processes, particularly in metabolic regulation and immune responses. Over the past two decades, emerging research has demonstrated that GPR84 regulates immune cell chemotaxis, phagocytosis, and inflammatory responses, playing a pivotal role in metabolic disorders, inflammatory diseases, and organ fibrosis.

Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection.

Glioblastoma (GBM) is a highly malignant tumor of the central nervous system that remains intractable despite advancements in current tumor treatment modalities, including immunotherapy. In recent years, metabolic checkpoints (aberrant metabolic pathways underlying the immunosuppressive tumor microenvironment) have gained attention as promising therapeutic targets and sensitive biomarkers across various cancers. Here, we briefly review the existing understanding of tumor metabolic checkpoints and their implications in the biology and management of GBM.

Integrative Analysis Identifies NSUN2 as an Essential Coordinator for Glioma Malignancy and Glucose Metabolism.

Background: Glioma, particularly glioblastoma, is the most common and aggressive primary brain tumor, with poor prognosis due to its metabolic heterogeneity. NSUN2, an m5C RNA methyltransferase and direct glucose sensor, has been implicated in various malignancies, but its role in glioma remains unclear.

Methods: Bioinformatic analysis was performed on multiple public databases and our glioma dataset from West China Hospital (WCH).

The impact of telomere length on the risk of idiopathic normal pressure hydrocephalus: a bidirectional Mendelian randomization study.

Idiopathic normal pressure hydrocephalus (iNPH) affects mainly aged populations. The gradual shortening of telomere length (TL) is one of the hallmarks of aging. Whereas the genetic contribution of TL to the iNPH is incompletely understood.

The impact of neurocognitive and psychiatric disorders on the risk of idiopathic normal pressure hydrocephalus: A bidirectional Mendelian randomization study.

Background: Neurocognitive and psychiatric disorders have been proved that they can comorbid more often with idiopathic normal pressure hydrocephalus (iNPH) than general population. However, the potential causal association between these disorders and iNPH has not been assessed. Thus, our study aims to investigate the causal relationship between them based on a bidirectional Mendelian randomization (MR) analysis.

MiR-185-5p suppresses HBV gene expression by targeting ELK1 in hepatoma carcinoma cells.

Aims: To investigate the role and underlying mechanism of miR-185-5p in hepatitis B virus (HBV) expression and replication.

Main Methods: The relative levels of hepatitis B surface antigen and hepatitis B e antigen were detected by enzyme-linked immunosorbent assay (ELISA). The HBV DNA copies in the cultures medium were measured by RT-qPCR.