98%
921
2 minutes
20
The study is aimed to virtually miniaturize medical implants produced of the biocompatible Ti with improved mechanical performance. The results on the simulation-driven design of medical implants fabricated of nanostructured commercially pure Ti with significantly enhanced mechanical properties are presented. The microstructure of initially coarse-grained Ti has been refined to ultrafine grain size by severe plastic deformation. The ultrafine-grained (UFG) Ti exhibits remarkably high static and cyclic strength, allowing to design new dental and surgical implants with miniaturized geometry. The possibilities to reduce the implant dimensions via virtual fatigue tests for the digital twins of two particular medical devices (a dental implant and a maxillofacial surgery plate) are explored with the help of finite element modeling. Additionally, the effect of variation in loading direction and the fixation methods for the tested implants are studied in order to investigate the sensitivity of the fatigue test results to the testing conditions. It is shown that the UFG materials are promising for the design of a new generation of medical products.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658747 | PMC |
http://dx.doi.org/10.3390/ma15217417 | DOI Listing |
CNS Neurosci Ther
September 2025
Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Aim: A total of 30% of individuals with epilepsy are resistant to drug treatment. Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) shows promise for treating drug-resistant epilepsy (DRE), but further research is needed to optimize DBS parameters, including stimulation frequency. This study aimed to reveal the optimal frequency for ANT-DBS by testing the real-time effects of various stimulation frequencies on the ANT among patients undergoing stereoelectroencephalography (SEEG) electrode implantation.
View Article and Find Full Text PDFBrain Behav
September 2025
Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Background And Purpose: White matter hyperintensity (WMH) impairs cognitive function but is not evident in the early stage, raising the need to explore the underlying mechanism. We aimed to investigate the potential role of network structure-function coupling (SC-FC coupling) in cognitive performance of WMH patients.
Methods: A total of 617 participants with WMH (mean age = 61 [SD = 8]; 287 females [46.
Cancer Immunol Immunother
September 2025
Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, China.
Objective: CircRNAs are involved in cancer progression. However, their role in immune escape in non-small cell lung cancer (NSCLC) remains poorly understood.
Methods: This study employed RIP-seq for the targeted enrichment of circRNAs, followed by Western blotting and RT-qPCR to confirm their expression.
Br J Ophthalmol
September 2025
Apgujeong St. Mary's Eye Center, Seoul, Korea (the Republic of).
Background/aims: In cytomegalovirus-induced anterior uveitis (CMV-AU), frequent recurrences are the primary cause of glaucomatous damage and corneal endothelial cell loss, yet factors influencing such recurrences remain unclear. Our study aims to investigate the impact of glaucoma surgery (GS) on recurrence rate in patients with CMV-AU.
Methods: This retrospective study included 149 immunocompetent patients with CMV-AU treated with antiviral medication following PCR confirmation.
J Prosthet Dent
September 2025
Associate Professor, School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan, ROC. Electronic address:
Statement Of Problem: While valued for their durability in dental prosthetics, polyaryletherketone (PAEK) materials, known for their chemical inertness and low surface energy, pose significant challenges in achieving durable adhesion to resin cements, a critical factor for the long-term success of dental restorations.
Purpose: This study evaluates the novel application of a methyl methacrylate-urethane dimethacrylate (MMA-UDMA) bonding primer following handheld nonthermal plasma (HNP) treatment to enhance the bonding performance and aging durability of PAEK materials with varying microfiller compositions, addressing the persistent challenge of achieving long-term adhesion in dental restorations.
Material And Methods: Three PAEK types, ceramic-filled polyetheretherketone (PEEK), titanium dioxide-filled polyetherketoneketone (PEKK), and PEEK with disk shape (Ø10×2.