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Article Abstract
1,3-Dipolar cycloaddition of nonstabilized azomethine ylides derived from α-C-H functionalization of tetrahydroisoquinoline for regio- and diastereoselective synthesis of spirooxindole-pyrrolidines is developed. A three-component reaction of readily available cyclic amine, aryl aldehydes, and olefinic oxindoles provides a pot, atom and step economy (PASE) approach for making spiro-heterocyclic compounds with biological interest.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496578 | PMC |
| http://dx.doi.org/10.1039/d1nj05538k | DOI Listing |
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