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Article Abstract
We herein report a palladium-catalyzed dearomative Heck/C(sp)-H activation/[4 + 2] decarboxylative cyclization of C2-tethered indoles. In this transformation, the alkylpalladium(II) species generated by indole dearomatization undergoes C-H activation to form ,-palladacycles, which are subsequently trapped by -bromobenzoic acids or cyclic β-bromoacrylic acids, enabling regio- and diastereoselective construction of hexacyclic and octocyclic fused indolines with a broad substrate scope.
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| http://dx.doi.org/10.1021/acs.joc.5c01929 | DOI Listing |
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