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Objectives: We developed a new Italian short version of the Geriatric Anxiety Scale (GAS-12) and evaluated its psychometric properties. The GAS-12 specifically screens for anxiety symptoms in the Italian older adult population by identifying items that best discriminate anxiety in this population.
Methods: In Study 1, we administered the full-length Italian translation of the GAS to 517 older adults and used item response theory to identify the most discriminating items and to develop the short form used in Study 2. In Study 2, we evaluated the functioning of the new short form of the questionnaire in a new sample of 427 older adults using Confirmatory factor analysis.
Results: Analyses indicated 12 items that discriminated well between anxious and non-anxious participants and distributed along the latent continuum of each trait. The GAS-12 fits a three-factor structure. There was also evidence for convergent and divergent validity.
Conclusions: The Italian GAS-12 appears to be a useful instrument for the quantitative screening of anxiety in Italian older adults.
Clinical Implications: Anxiety imposes significant impairment thus making imperative the screening and assessment of anxiety symptoms. The GAS-12 is particularly indicated with limited time and many scales in a clinical assessment or research protocols.
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http://dx.doi.org/10.1080/07317115.2022.2120445 | DOI Listing |
Int J Pharm
September 2025
Department of Veterinary Medicine, Central Animal Facility, Amrita Institute of Medical Sciences and Research Centre, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, Kerala 682041, India.
The clinical use of gemcitabine (GEM), a frontline chemotherapeutic agent for pancreatic ductal adenocarcinoma (PDAC), is limited by its short half-life, rapid systemic clearance, associated dose-limiting toxicities and a faster development of resistance in pancreatic cancer. Aspirin (ASP), a repurposed NSAID, has been shown to sensitize PDAC cells to GEM through modulation of multiple oncogenic and inflammatory pathways. However, its clinical use is restricted by dose-dependent gastrointestinal toxicity.
View Article and Find Full Text PDFEvent-based sensors (EBS), with their low latency and high dynamic range, are a promising means for tracking unresolved point-objects. Conventional EBS centroiding methods assume the generated events follow a Gaussian distribution and require long event streams ($\gt 1$s) for accurate localization. However, these assumptions are inadequate for centroiding unresolved objects, since the EBS circuitry causes non-Gaussian event distributions, and because using long event streams negates the low-latency advantage of EBS.
View Article and Find Full Text PDFJAMA Intern Med
September 2025
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts.
Importance: Hospitals have reported growing difficulty in discharging patients in a timely manner, often citing bottlenecks in postacute care. Medicare Advantage plans, now the dominant form of Medicare coverage, may contribute to these delays due to administrative and network constraints, yet national evidence is lacking.
Objective: To quantify changes in hospital length of stay for Medicare Advantage vs traditional Medicare beneficiaries.
Int Urogynecol J
September 2025
Department of Gynecology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, 528308, PR China.
Introduction And Hypothesis: This study aimed to evaluate the effectiveness of platelet-rich plasma (PRP) combined with fractional CO laser therapy in women diagnosed with mild or moderate stress urinary incontinence (SUI).
Methods: In this single-center, single-blinded, randomized controlled trial, 69 women diagnosed with mild or moderate SUI were randomly assigned to receive fractional CO laser therapy, PRP injections, or a combination of both treatments (n = 23 per group). Each participant underwent three treatment sessions at 30-day intervals.
J Labelled Comp Radiopharm
September 2025
National Key Laboratory for the Development and Utilization of Forest Food Resources, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing, Jiangsu, China.
Carbon-11 (C)-labeled radiotracers are invaluable tools in positron emission tomography (PET), enabling real-time visualization of biochemical processes with high sensitivity and specificity. Among the various C synthons, cyclotron-produced [C]CO is a fundamental precursor, though its direct incorporation into complex molecules has traditionally been limited by its low reactivity, gaseous form, and short half-life. Recent advances in [C]CO fixation chemistry through both nonphotocatalytic and photocatalytic methods have significantly expanded its utility in the synthesis of structurally diverse compounds, including carboxylic acids, carbonates, carbamates, amides, and ureas.
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