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Purpose: To describe a transconjunctival technique for full-thickness (excisional) optic nerve biopsy.
Method: A medial transconjunctival approach to the optic nerve with disinsertion of the medial rectus is used. A small right-angle Mixter forcep is used to clamp the optic nerve far posteriorly, and then a microscalpel is directed metal-on-metal to cut the posterior optic nerve. The cut nerve is then rotated anteriorly to complete the proximal nerve cut.
Result: A full-thickness specimen of 11 mm of more can be obtained without undue traction on the globe. The globe remains viable.
Conclusion: A long length, excisional optic nerve biopsy can be readily and safely performed without endoscopic techniques.
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http://dx.doi.org/10.1080/01676830.2022.2114502 | DOI Listing |
Invest Ophthalmol Vis Sci
September 2025
Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, United States.
Purpose: To assess macular choriocapillaris (CC) metrics in healthy volunteers (HVs) without ocular disease and demonstrate CC variations in patients with inherited retinal dystrophies (IRDs) using adaptive optics optical coherence tomography angiography (AO-OCTA).
Methods: Twenty-one HVs and three IRD patients were imaged. Macular variation in 20 HVs in CC metrics (CC density, CC diameter, CC tortuosity, void diameter, void area, lobule count, lobule area, and RPE-CC distance) were assessed by imaging a 28° strip of overlapping AO-OCTA volumes (3° × 3°) from the optic nerve head to the temporal macula.
Cureus
August 2025
Faculty of Medicine, University of Costa Rica, San Jose, CRI.
This systematic review examines the potential association between semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, and the development of non-arteritic anterior ischemic optic neuropathy (NAION). Nine studies were included, consisting of retrospective cohort analyses, case series, and pharmacovigilance reports. Findings across the literature were inconsistent, with some studies reporting an increased risk while others found no significant association.
View Article and Find Full Text PDFCureus
August 2025
Emergency Medicine, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Background Increased intracranial pressure (ICP) can be reliably detected at the bedside using the optic nerve sheath diameter (ONSD). The functional outcome in stroke patients can be predicted with the use of acute-phase ONSD dynamics. Objectives To determine the predictive accuracy of ONSD on days 0, one, and three for the prognosis of ischemic stroke patients presented to emergency medicine as measured by Modified Rankin Scale (mRS) score.
View Article and Find Full Text PDFNat Commun
September 2025
Shanghai Yao Yuan Biotechnology Ltd (Drug Farm), Shanghai, China.
ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome is a rare genetic disease caused by variants in alpha-kinase 1 (ALPK1) resulting in downstream pro-inflammatory signaling mediated by the TIFA/TRAF6/NF-κB pathway. Here, we report the design of an ALPK1 inhibitor, DF-003, with pharmacokinetic properties suitable for daily oral dosing. In biochemical assays, DF-003 potently inhibits human ALPK1 (IC = 1.
View Article and Find Full Text PDFOphthalmic Plast Reconstr Surg
September 2025
Purpose: During endoscopic endonasal access to small intraconal masses deep in the orbital apex, a line of fusion between inferior and medial recti is encountered distal to the termination of the common tendinous ring. The intraoperatively viewed length of this segment has not been quantified. To assist clinical recognition of this structure, our study quantifies its length and proposes the standardized nomenclature term of inferomedial extraocular muscle raphe (IM-EOMR).
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