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Article Abstract
The signaling adaptor MAVS is a critical determinant in retinoic acid-inducible gene 1-like receptor signaling, and its activation is tightly controlled by multiple mechanisms in response to viral infection, including phosphorylation and ubiquitination. In this article, we demonstrate that zebrafish , one of the sirtuin family proteins, negatively regulates mavs-mediated antiviral innate immunity. is induced by spring viremia of carp virus (SVCV) infection and binds to mavs, resulting in attenuating phosphorylation and ubiquitination of mavs. Disruption of in zebrafish promotes survival ratio after challenge with SVCV. Consistently, the antiviral responsive genes are enhanced, and the replication of SVCV is diminished in -dificient zebrafish. Therefore, we reveal a function of zebrafish in the negative regulation of antiviral innate immunity by targeting mavs.
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| http://dx.doi.org/10.4049/jimmunol.2100983 | DOI Listing |
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