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The field of magnetic robotics aims to obviate physical connections between the actuators and end-effectors. Such tetherless control may enable new ultra-minimally invasive surgical manipulations in clinical settings. While wireless actuation offers advantages in medical applications, the challenge of providing sufficient force to magnetic needles for tissue penetration remains a barrier to practical application. Applying sufficient force for tissue penetration is required for tasks such as biopsy, suturing, cutting, drug delivery, and accessing deep seated regions of complex structures in organs such as the eye. To expand the force landscape for such magnetic surgical tools, an impact-force based suture needle capable of penetrating and samples with 3-DOF planar motion is proposed. Using custom-built 14G and 25G needles, we demonstrate generation of 410 mN penetration force, a 22.7-fold force increase with more than 20 times smaller volume compared to similar magnetically guided needles. With the MPACT-Needle, suturing of a gauze mesh onto an agar gel is demonstrated. In addition, we have reduced the tip size to 25G, which is a typical needle size for interventions in the eye, to demonstrate penetration in a rabbit eye, mimicking procedures such as corneal injections and transscleral drug delivery.
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http://dx.doi.org/10.1002/aisy.202200072 | DOI Listing |
Surg Case Rep
September 2025
Department of Pathology, Self-Defense Forces Central Hospital, Tokyo, Japan.
Introduction: Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm that most commonly originates in the pleura but can also occur at extrapleural sites, including the abdominal cavity. Among these, primary SFT of the stomach is exceptionally rare. Due to overlapping clinical, endoscopic, and radiologic characteristics, distinguishing SFT from gastrointestinal stromal tumor (GIST) can be particularly challenging.
View Article and Find Full Text PDFPLoS Negl Trop Dis
September 2025
The Kirby Institute, University of New South Wales, Sydney, Australia.
Trachoma, caused by repeated ocular infection with Chlamydia trachomatis, remains a leading infectious cause of blindness globally, with significant implications for public health. The World Health Organization and partners aim to eliminate trachoma as a public health problem by 2030, targeting specific prevalence thresholds for trachomatous trichiasis (TT) and trachomatous inflammation-follicular (TF). Diagnosis is primarily clinical.
View Article and Find Full Text PDFInt J Vitam Nutr Res
August 2025
Department of Plastic and Cosmetic Center, The First Affiliated Hospital, Zhejiang University, 310003 Hangzhou, Zhejiang, China.
The vitamin B complex, a group of water-soluble vitamins, is essential for various metabolic and cellular processes and critical for achieving optimal surgical outcomes in plastic and cosmetic procedures. This review examines the mechanistic contributions of this complex at the cellular level, including any roles in mitochondrial bioenergetics, redox balance, gene regulation, and cellular repair mechanisms. Niacinamide, as a precursor to NAD⁺, enhances mitochondrial efficiency and facilitates energy production, supporting tissue regeneration.
View Article and Find Full Text PDFFront Bioeng Biotechnol
August 2025
Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Electroactive polymer (EAP) artificial muscles are gaining attention in robotic control technologies. Among them, the development of self-sensing actuators that integrate sensing mechanisms within artificial muscles is highly anticipated. This study aimed to evaluate the accuracy and precision of the sensing capabilities of the e-Rubber (eR), an artificial muscle developed by Toyoda Gosei Co.
View Article and Find Full Text PDFLangmuir
September 2025
School of Energy and Power Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
In the stable cone-jet regime, liquid usually presents the shape of a cone extended by a jet at its apex, with jet breakup yielding fine drops. The dynamics of the Taylor cone critically affect the stability of the jet and further determine the jet and/or drop size. In the present work, the morphology of the Taylor cone, cone length, and cone angle were studied through experimental and numerical means, where the operating parameters and liquid properties are considered.
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