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A methoxynaphthalene benzothiazole conjugate (MNBTZ) armed with CC vinylic double bonds was synthesized and utilized for the selective detection of CN ions. The probe showed yellow fluorescence due to ICT from the methoxynaphthalene moiety to benzothiazole, which instantly changed to light purple upon the nucleophilic addition of CN to the vinylic double bond, inhibiting ICT due to the break-in conjugation. The effectiveness of the probe was proved by this brilliant ratiometric fluorescence change, which was achieved selectively as observed by experiments with competing anions. H NMR titrations and DFT calculations support this mechanism. A low detection limit of 2.1(±0.0022) × 10 M along with good fluorescence color change on solid TLC plates and human breast cancer cells makes it amenable to CN sensing.
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http://dx.doi.org/10.1039/d2ay00898j | DOI Listing |
Med Oncol
September 2025
Department of Biotechnology, Institute of Engineering and Management, University of Engineering and Management, Kolkata, Kolkata, India.
Oligomeric proanthocyanidins (OPCs), condensed tannins found plentiful in grape seeds and berries, have higher bioavailability and therapeutic benefits due to their low degree of polymerization. Recent evidence places OPCs as effective modulators of cancer stem cell (CSC) plasticity and tumor growth. Mechanistically, OPCs orchestrate multi-pathway inhibition by destabilizing Wnt/β-catenin, Notch, PI3K/Akt/mTOR, JAK/STAT3, and Hedgehog pathways, triggering β-catenin degradation, silencing stemness regulators (OCT4, NANOG, SOX2), and stimulating tumor-suppressive microRNAs (miR-200, miR-34a).
View Article and Find Full Text PDFAnn Surg Oncol
September 2025
Section of Surgical Oncology, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Background: Postmastectomy autologous reconstruction (PMAR) is an important component of comprehensive breast cancer care. Previous research has suggested the existence of sociodemographic disparities in complications after immediate PMAR. The objective of this study was to examine the impact of sociodemographic and clinical factors on immediate PMAR postoperative outcomes.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
September 2025
Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Targeted intraoperative radiotherapy (IORT) delivers a single dose of radiation to a fresh tumour bed immediately after lumpectomy, commonly used to treat early breast cancer (EBC). It is delivered during the same sitting, with improved patient compliance and better sparing of adjacent healthy tissue, compared to conventional adjuvant radiotherapy to the whole breast. The recently published 12-year results (median follow up of 8.
View Article and Find Full Text PDFInflamm Res
September 2025
Department of General Surgery, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Chaoyang District, Beijing, 100029, China.
Background: The roles of long non-coding RNAs (lncRNAs) in the progression of various human tumors have been extensively studied. However, their specific mechanisms and therapeutic potential in Triple-Negative Breast Cancer (TNBC) remain to be fully elucidated.
Materials And Methods: The qRT-PCR assay was utilized to assess the relative mRNA levels of TFAP2A-AS1, PHGDH, and miR-6892.