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Nonunion is known to be a relatively common complication following ankle arthrodesis. Various fixation techniques have been introduced to enhance the stability and to improve fusion rate. With the use of anterior plate supplementation, postoperative wound problems have been frequently reported despite better fusion rate. This study was performed to determine the effects of tibialis anterior (TA) tenotomy on wound complications and functional outcomes after anterior fusion plating for severe ankle arthritis. Forty-six patients who underwent ankle arthrodesis using anterior fusion plate were followed for more than 2 years. TA tenotomy was performed prior to wound closure in all patients. As a control group, 38 patients who underwent arthrodesis without TA tenotomy were analyzed. Functional outcomes were evaluated with Ankle Osteoarthritis Scale and Foot and Ankle Ability Measure. Wound complication rate, time to fusion, fusion rate, time to pain relief were evaluated. Mean Ankle Osteoarthritis Scale and Foot and Ankle Ability Measure scores significantly improved to 32.6 and 69.4 points at final follow-up, respectively. As compared to control group (33.8 and 67.7 points), there were no significant differences in functional outcomes. As postoperative wound complications, there were 1 case of wound dehiscence and 1 case of superficial wound infection. TA tenotomy group showed a significantly lower wound complication rate (4.3%) than control group (23.7%) (p < .001). While there were no significant differences in fusion rate, time to fusion, and time to pain relief between both groups, control group needed higher rate of implant removal. Ankle arthrodesis using anterior fusion plate in conjunction with TA tenotomy appears to be an effective surgical option for end-stage ankle arthritis, with excellent fusion rate and less wound complication rate. Although there were no specific functional deficits related to absence of TA tendon, further studies are needed to determine long-term effects of TA tenotomy in patients with a fused ankle.
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http://dx.doi.org/10.1053/j.jfas.2022.06.014 | DOI Listing |
Health Inf Sci Syst
December 2025
School of Information Science and Automation, Northeastern University, Shenyang, 110819 China.
Accurate prediction of drug-target interactions (DTIs) is crucial for improving the efficiency and success rate of drug development. Despite recent advancements, existing methods often fail to leverage interaction features at multiple granular levels, resulting in suboptimal data utilization and limited predictive performance. To address these challenges, we propose CF-DTI, a coarse-to-fine drug-target interaction model that integrates both coarse-grained and fine-grained features to enhance predictive accuracy.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Objective: To investigate the clinicopathological features, diagnostic value, risk model and prognostic significance of epithelioid hemangioendothelioma (EHE) in a retrospective cohort of 115 cases.
Methods: A total of 115 cases of EHE diagnosed in the Cancer Hospital of the Chinese Academy of Medical Sciences (NCC) from 2011 to 2023 were collected. The clinical and pathological features of EHE were reviewed by Fluorescence hybridization (FISH) and Immunohistochemistry (IHC).
Int J Comput Assist Radiol Surg
September 2025
The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China.
Purpose: To enhance the temporal feature learning capability of the laparoscopic cholecystectomy phase recognition model and address the class imbalance issue in the training data, this paper proposes an Xception-dual-channel LSTM fusion model based on a dynamic data balancing strategy.
Methods: The model dynamically adjusts the undersampling rate for each surgical phase, extracting short video clips from the original data as training samples to balance the data distribution and mitigate biased learning. The Xception model, utilizing depthwise separable convolutions, extracts fundamental visual features frame by frame, which are then passed to a dual-channel LSTM network.
Lab Invest
September 2025
Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA. Electronic address:
Sinonasal mucosal melanoma (SNMM) is a rare aggressive malignancy of the sinonasal tract. Due to its advanced clinical presentation and frequent late-stage diagnosis, the 5-year survival rate is less than 30%, with an even worse prognosis in patients with distant metastasis (SNMM-M). Therefore, characterizing the molecular landscape of SNMM may provide novel therapeutic targets for SNMM-M.
View Article and Find Full Text PDFBioorg Chem
September 2025
Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. Electronic address:
RET tyrosine kinase, a key regulator of cellular signaling, is abnormally activated due to mutations or fusions in various cancers, making it an important therapeutic target. Traditional multi-kinase inhibitors (MKIs, such as cabozantinib and vandetanib) exhibit significant side effects due to non-selective inhibition of targets like VEGFR, and also suffer from resistance associated with RET mutations (e.g.
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