Anesthesia: Synaptic power failure.

Curr Biol

Department of Anesthesiology and Critical Care, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

Published: July 2022


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Article Abstract

One of the greatest unresolved mysteries in medicine relates to the molecular and neuronal mechanisms through which general anesthetics abolish perception. A new study in mice with mutations affecting mitochondrial complex 1 suggests that anesthetic-disruption of cellular energetics impairs endocytosis to alter synaptic function.

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http://dx.doi.org/10.1016/j.cub.2022.06.043DOI Listing

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