Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the leading cause of coronavirus disease-2019 (COVID-19), is an emerging global health crisis. Lung cancer patients are at a higher risk of COVID-19 infection. With the increasing number of non-small-cell lung cancer (NSCLC) patients with COVID-19, there is an urgent need of efficacious drugs for the treatment of COVID-19/NSCLC. Based on a comprehensive bioinformatic and systemic biological analysis, this study investigated COVID-19/NSCLC interactional hub genes, detected common pathways and molecular biomarkers, and predicted potential agents for COVID-19 and NSCLC. A total of 122 COVID-19/NSCLC interactional genes and 21 interactional hub genes were identified. The enrichment analysis indicated that COVID-19 and NSCLC shared common signaling pathways, including cell cycle, viral carcinogenesis, and p53 signaling pathway. In total, 10 important transcription factors (TFs) and 44 microRNAs (miRNAs) participated in regulations of 21 interactional hub genes. In addition, 23 potential candidates were predicted for the treatment of COVID-19 and NSCLC. This study increased our understanding of pathophysiology and screened potential drugs for COVID-19 and NSCLC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201692 | PMC |
| http://dx.doi.org/10.3389/fphar.2022.857730 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Pilot Study on Quantitative Accuracy and Radiomic Feature Stability of Deep Progressive Learning Reconstruction in NSCLC PET.
J Imaging Inform Med
September 2025
Department of Radiology, Fujita Health University Hospital, Toyoake, Aichi, Japan.
Deep progressive learning reconstruction (DPR) is a novel deep learning-based algorithm for PET imaging, yet its impact on quantitative metrics and radiomic feature stability is not fully characterized. This preliminary study systematically evaluated DPR against conventional ordered-subset expectation maximization (OSEM) in non-small cell lung cancer (NSCLC) PET imaging. In this retrospective study of 24 NSCLC patients, PET data were reconstructed using OSEM and three DPR strength levels.
View Article and Find Full Text PDFMultifunctional regulation and treatment of ubiquitin specific protease 10.
Biochem Pharmacol
August 2025
School of Life Science, Beijing Institute of Technology, Beijing 100081, China; Advanced Technology Research Institute, Beijing Institute of Technology, Jinan 250307, China. Electronic address:
USP10 is a critical deubiquitinating enzyme within the ubiquitin-specific protease family, playing multifaceted roles in cellular physiology and disease pathogenesis. Structurally composed of a G3BP1-interacting motif, a N-terminal domain (mediating most protein interactions), and a catalytic USP domain (residues 415-795, catalytic triad C424-H736-D751), USP10 regulates diverse cellular pathways by stabilizing key proteins through deubiquitination. It exhibits context-dependent functional duality, particularly in cancer: USP10 promotes tumorigenesis in various cancers (e.
View Article and Find Full Text PDFImpact of the COVID-19 Pandemic on Diagnosis and Multidisciplinary Treatment of NSCLC in Ontario, Canada.
JTO Clin Res Rep
September 2025
Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Introduction: The coronavirus disease 2019 pandemic disrupted cancer care delivery globally, with many jurisdictions reporting reductions in lung cancer diagnoses and delays in treatment. In Ontario, Canada, both institutional and provincial data have reported mixed trends in NSCLC presentation and care. This study aimed to assess the short-term impact of the coronavirus disease 2019 pandemic on NSCLC diagnoses and treatment pathways across Ontario using population-level data from Cancer Care Ontario administrative health databases.
View Article and Find Full Text PDFRemoval of EpCAM-positive tumor cells during intraoperative blood salvage- A pivotal multicenter clinical study (REMOVE).
J Clin Anesth
September 2025
Goethe University, University Hospital Frankfurt, Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Background: Intraoperative blood salvage can reduce the need for allogeneic blood transfusions, minimizing immunological risks and infection by reusing the patient's own blood. However, in cancer surgery, a key concern limiting its use is the potential reintroduction of viable cancer cells. Additional risks, such as infection and coagulopathy, have also contributed to its limited adoption.
View Article and Find Full Text PDFEarly-stage resectable non-small cell lung cancer in Hungary.
Pathol Oncol Res
August 2025
Department of Oncopulmonology, Pulmonology Center of the Reformed Church in Hungary, Törökbálint, Hungary.
This study provides a comprehensive analysis of early-stage resectable non-small cell lung cancer (NSCLC) in Hungary, investigating incidence rates, demographic trends, treatment patterns and survival outcomes. We used data from the National Health Insurance Fund (NHIF) spanning 2013-2022, and we analyzed 6,571 patients with available NSCLC histology and no metastasis, who underwent curative surgery within 6 months of diagnosis, and evaluated epidemiological trends and the use of neoadjuvant and adjuvant therapies. For the efficacy analysis, we narrowed the patient cohort to 5,494 patients diagnosed and treated between 2013 and 2019 with at least three-year follow-up data.
View Article and Find Full Text PDF