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As one of the typical fluorescent cores, dicyanomethylene-4H-pyran (DCM) derivatives exhibit excellent photophysical and photochemical properties, such as large Stokes shift, excellent light stability, and tunable near-infrared (NIR) emission. The luminescence mechanism of DCM probes mainly depends on the intramolecular charge transfer (ICT). Hence, by regulating the ICT process, the probes can specifically act on the target molecule. Accordingly, a series of NIR DCM probes have been constructed to detect the ions, reactive oxygen species (ROS), and biological macromolecules in cells. However, there is no relevant review to summarize it at present. This minireview mainly summarizes the NIR DCM probes based on ICT effect and their applications in biosensors and biological imaging in recent years. This will be beneficial to innovatively construct new DCM probes and actively promote their application in the future.
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http://dx.doi.org/10.3389/fchem.2022.903253 | DOI Listing |
Chem Commun (Camb)
September 2025
Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803-1804, USA.
Understanding proton transfer at the aqueous graphene oxide (GO) interface is essential for developing and designing GO-based proton exchange membranes for fuel cells. By comparing GO sheets with two different oxidation levels using deep potential molecular dynamics (DPMD) simulations, we find that oxidized GO promotes interfacial proton release while reduced GO adsorbs protons.
View Article and Find Full Text PDFBiosens Bioelectron
December 2025
School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China. Electronic address:
Parkinson's disease (PD) is a common neurodegenerative disorder with complex pathogenesis. Ferroptosis, an iron-regulated cell death driven by lipid peroxidation, is closely linked to PD progression. Excessive hydroxyl radical (•OH) accumulation can cause severe neural damage and is associated with neurodegenerative diseases, but its role in PD remains unclear.
View Article and Find Full Text PDFAntioxidants (Basel)
May 2025
Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR, China.
(GA), a polyphenolic compound derived from amur maple trees, has been identified as a powerful scavenger of reactive oxygen species (ROS). Recognizing the pivotal role of ROS in exacerbating secondary damage during myocardial ischemia-reperfusion injury (MIRI), we fractionated GA-enriched extracts from the leaves of the amur maple tree, L. subsp.
View Article and Find Full Text PDFChem Commun (Camb)
July 2025
Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa, Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Tec
Near-infrared (NIR) chemiluminescent probes offer high sensitivity for biological sensing applications. Herein, we present two NIR chemiluminescent probes for leucine aminopeptidase (LAP) detection, designed by covalently linking the dicyanomethylene-4-pyran (DCM) fluorophore to Schaap's dioxetane scaffold. The impact of substitution position on chemiluminescence kinetics and enzymatic responsiveness revealed that only the -substituted probe with minimal steric hindrance enables efficient and imaging of LAP activity.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
May 2025
Department of Traditional Chinese Medicine, Shangfang Community Health Service Center,Dongshan Street, Jiangning District Nanjing 211103,China.
This study explores the role and underlying molecular mechanisms of fucoidan sulfate(FPS) in regulating heme oxygenase-1(Hmox1)-mediated ferroptosis to ameliorate myocardial injury in diabetic cardiomyopathy(DCM) through in vivo and in vitro experiments and network pharmacology analysis. In vivo, a DCM rat model was established using a combination of "high-fat diet feeding + two low-dose streptozotocin(STZ) intraperitoneal injections". The rats were randomly divided into four groups: normal, model, FPS, and dapagliflozin(Dapa) groups.
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