Antagonistic activity and mode of action of trypacidin from marine-derived against .

3 Biotech

Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, 222005 China.

Published: June 2022


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Article Abstract

This study aimed to investigate the antagonistic activity and mode of action of trypacidin from marine-derived against . Results indicated that the minimal inhibitory concentration and minimal bactericidal concentration of trypacidin against were 31.25 and 62.5 μg/mL, respectively, which was better than that of streptomycin sulfate. Trypacidin remarkably inhibited the growth of and had a strong destructive effect on cell wall permeability and integrity, cell membrane permeability, and morphological alterations. Its potential as an antibacterial agent for aquatic products must be further explored.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123130PMC
http://dx.doi.org/10.1007/s13205-022-03194-3DOI Listing

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