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Flexible multichannel electrode arrays (fMEAs) with multiple filaments can be flexibly implanted in various patterns. It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands. This study proposed a strategy for reducing the microelectrode volume with integrated packaging. An implantation system was developed specifically for semiautomatic distributed implantation. The feasibility and convenience of the fMEA and implantation platform were verified in rodents. The acute and chronic recording results provied the effectiveness of the packaging and implantation methods. These methods could provide a novel strategy for developing fMEAs with more filaments and recording sites to measure functional interactions across multiple brain regions.
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http://dx.doi.org/10.1038/s41378-022-00366-2 | DOI Listing |
Front Bioeng Biotechnol
August 2025
Department of Orthopaedics, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Objective: Due to its inherent high instability, the selection of fixation strategies for unilateral Denis type II sacral fractures remains a controversial challenge in the field of traumatic orthopedics. This study focuses on unilateral Denis type II sacral fractures. By applying three different fixation methods, it aims to explore their biomechanical properties and provide a theoretical basis for optimizing clinical fixation protocols.
View Article and Find Full Text PDFProc Biol Sci
September 2025
Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, 901 83 Umeå, Västerbotten County, Sweden.
Pharmaceutical contaminants reaching natural aquatic ecosystems can affect fish behaviour, modifying activity patterns, foraging behaviour and antipredator responses. While laboratory-based studies can offer key insights, assessing the ecological relevance of these findings requires field-based approaches. Therefore, we examined the effects of oxazepam, a widely prescribed anxiolytic drug, on the behaviour of a cyprinid fish (the common roach, ) in the wild, combining slow-release exposure implants with continuous tracking via acoustic telemetry.
View Article and Find Full Text PDFBrain
September 2025
Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, 13005 Marseille, France.
The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric disorders. While transcranial brain stimulation treatments often target the LPFC, our current understanding of connectivity profiles guiding these interventions based on electrophysiology remains limited. Here, we present a high-resolution probabilistic map of bidirectional effective connectivity between the LPFC and widespread cortical and subcortical regions.
View Article and Find Full Text PDFPLoS One
September 2025
Mechanical and Nuclear Engineering Department, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Sectionally nonlinearly functionally graded (SNFG) structures with triply periodic minimal surface (TPMS) are considered ideal for bone implants because they closely replicate the hierarchical, anisotropic, and porous architecture of natural bone. The smooth gradient in material distribution allows for optimal load transfer, reduced stress shielding, and enhanced bone ingrowth, while TPMS provides high mechanical strength-to-weight ratio and interconnected porosity for vascularization and tissue integration. Wherein, The SNFG structure contains sections with thickness that varies nonlinearly along their length in different patterns.
View Article and Find Full Text PDFUnfallchirurgie (Heidelb)
September 2025
Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude W1, 48149, Münster, Deutschland.
The bony consolidation of fractures depends on various factors. Under optimal conditions fracture healing takes place within a few weeks. An essential requirement for fracture healing is the restoration of adequate biomechanical stability with an interfragmentary movement which is as ideal as possible.
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