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Background: Distressful and negative affective states can be associated with limited self-regulation capacities, while emotion regulation processes (e.g., rumination, negative urgency) might contribute to further depletion of self-control capacities which in turn can lead to diminished control over cannabis use.
Aims: The mediating functions of rumination (i.e., brooding and reflection), negative urgency (NU) and constructs of cannabis use regulation (i.e., cannabis protective behavioral strategies [CPBS] and cannabis refusal self-efficacy [CRSE]) were examined on the associations between anxious-depressive symptoms and cannabis use outcomes (i.e., frequency, harmful use).
Methods: The cross-sectional study used a sample of cannabis users showing signs of harmful consumption (N = 750; Males: 70.13% [N = 526]; Age: M = 29.11 [SD = 7.45]). Standardized questionnaires measured anxious-depressive symptoms, rumination, NU, CRSE, CPBS, frequency of cannabis use and harmful cannabis use. A linear regression-based, double-mediation model was performed.
Results: Five significant indirect effects were demonstrated in the mediation model. Single-mediation effects were shown between anxious-depressive symptoms and harmful cannabis use via CRSE and via CPBS. Double-mediation effects were presented between anxious-depressive symptoms and harmful cannabis use via reflection and CPBS, via reflection and CRSE, and via NU and CRSE.
Conclusions: Emotion and cannabis use regulation pathways explained the associations between anxious-depressive symptoms and harmful cannabis use. The mediation model provided new details on how anxious-depressive symptoms, rumination and NU might lead to harmful cannabis use via regulation of cannabis use. Limited self-regulation capacities and similarities between emotion and cannabis use regulation processes might explain the identified indirect effects.
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http://dx.doi.org/10.1016/j.comppsych.2022.152320 | DOI Listing |
Transl Psychiatry
September 2025
Université Claude Bernard Lyon 1, Lyon Neuroscience Research Center, CNRS, INSERM, Lyon, France.
Rapid-acting antidepressants (RAADs) such as ketamine are currently under development. The aim of this study is to characterize the neural circuits affected by ketamine and NLX-101, a selective 5-HT receptor biased agonist which has shown promising effects, by using [F]FDG PET imaging in rats that had received chronic administration of corticosterone (CORT), a model of anxiety-depression. In a longitudinal study, regional changes in brain activity were investigated in 24 selected CORT rats.
View Article and Find Full Text PDFJ Am Coll Health
August 2025
Center for Pediatric Psychology, Department of Psychology, Oklahoma State University, Stillwater, Oklahoma, USA.
Emerging adults with chronic medical conditions (CMCs) are at elevated risk for internalizing (i.e., anxious/depressive) symptoms.
View Article and Find Full Text PDFBMC Geriatr
August 2025
Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
We report an atypical case of Creutzfeldt-Jakob Disease (CJD) mimicking Frontotemporal Dementia (FTD) in a 68-year-old male. The patient initially presented with an anxious-depressive syndrome, progressing over 29 months to include dysexecutive syndrome, stereotyped speech, inertia, social withdrawal, verbal fluency impairments, and marked dyspraxia. Diagnostic imaging revealed signal alterations on MRI, while CSF analysis showed elevated T-TAU, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) levels.
View Article and Find Full Text PDFFront Psychol
July 2025
School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom.
Introduction: Outcome uncertainty is known to engage motivational and emotional phenomena. However, there remain questions as to how outcome uncertainty related to gain and loss and information availability via performance feedback interact to impact motivational and emotional phenomena: (1) generally, and (2) in relation to individual differences in intolerance of uncertainty, and current symptoms related to anxiety and depression.
Methods: To address these gaps in the literature, we manipulated the level of outcome uncertainty (gain, loss, none) and performance feedback (present, absent) during an online cognitive control task ( = 69), to examine how these factors impact different read-outs: subjective emotional responses (valence, arousal), task accuracy, reaction times, and fixation count.
Cells
July 2025
Center of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom 2531, South Africa.
(ST) induces antidepressant and anxiolytic effects, purportedly by monoamine regulation, anti-inflammatory and antioxidant properties, and phosphodiesterase 4 (PDE4) inhibition. These multimodal actions have not been demonstrated in an animal model of major depressive disorder. Wistar rats (both sexes) were subjected to 8-week unpredictable chronic mild stress, subsequently receiving saline, a standardized ST extract, Zembrin 25 and 12.
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