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Background: People with arthritis, a leading cause of disability, may be prescribed long-term opioid therapy to manage chronic pain. Regular use of opioids can increase risk of overdose and opioid use disorder (OUD).
Objective: The purpose of our research was to validate an instrument to screen for harmful opioid use in people with disability and chronic pain due to arthritis (PWDA).
Methods: We tested the Current Opioid Misuse Measure (COMM), an instrument designed for monitoring people with chronic pain on long-term opioids, with 318 PWDA who are taking long term opioids from February-June 2020. We validated the COMM against a Diagnostic and Statistical Manual for Mental Health Disorders, 5th edition (DSM-V) assessment instrument and risk factors for OUD. Final item selection was based on advisory group input, cognitive testing, and empirical evaluation of items. We calculated a cutoff score using receiver operating characteristic (ROC) analysis.
Results: Of the 17 items on the original COMM, we found that 11 items measured the intended construct-opioid use in a way that causes harm in PWDA. Once limiting the instrument to these 11 items (The COMM 11-PWDA), the items had excellent internal consistency and validity with the DSM-V measure. Reasonable sensitivity and specificity were established.
Conclusions: The COMM 11-PWDA is a valid instrument for screening for and monitoring harmful opioid use in PWDA.
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http://dx.doi.org/10.1016/j.dhjo.2022.101296 | DOI Listing |
Arch Gerontol Geriatr
August 2025
Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, China. Electronic address:
Background: Frailty is a dynamic condition that may affect mental health. This study aimed to investigate the associations of frailty and its changes with the risks of depressive symptoms across multiple regions in aging populations.
Methods: Data were drawn from five cohort studies in the United States, England, Europe, China, and Mexico.
Am J Reprod Immunol
September 2025
Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
Problem: Endometriosis is a chronic inflammatory disease that leads to pelvic pain and infertility. Recent studies have indicated that immunological, endocrine, biochemical, and genetic irregularities, along with suboptimal quality of oocytes, embryos, and the endometrial environment, significantly impact infertility associated with endometriosis. Ectopic endometrial cells in endometriosis have the capacity to avoid apoptosis.
View Article and Find Full Text PDFPLoS One
September 2025
Department Chemicals and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Tattoos and permanent make-up (PMU) gain increasing popularity among the general population. There are indications that pigments or their fragments may translocate within the body, however knowledge about possible systemic adverse effects related to tattoos is very limited. We investigated the prevalence of systemic chronic health effects including cardiovascular diseases, cancer and liver toxicity and their relationship with the presence and characteristics of tattoos and PMU as part of the LIFE-Adult-study, a population-based cohort study.
View Article and Find Full Text PDFJ Drug Target
September 2025
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Background: Chronic constriction injury (CCI) of the sciatic nerve induces neuropathic pain, inflammation, oxidative stress, and neurodegenerative changes, impairing sensory and emotional function. While curcumin is well recognized for its anti-inflammatory and neuroprotective properties, its therapeutic use is limited by poor bioavailability. Curcumin liposomal nanoparticles (CLNs) offer improved delivery and stability.
View Article and Find Full Text PDFRheumatology (Oxford)
September 2025
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Objectives: Osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide, traditionally viewed as a disease of aging. However, emerging evidence highlights its increasing prevalence among middle-aged adults (40-59 years), a population critical to socioeconomic stability. This study is designed to assess the burden of OA among middle-aged adults.
View Article and Find Full Text PDF