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Interference can degrade the detection performance of a radar system. To overcome the difficulty of target detection in unknown interference, in this paper we model the interference belonging to a subspace orthogonal to the signal subspace. We design three effective detectors for distributed target detection in unknown interference by adopting the criteria of the generalized likelihood ratio test (GLRT), the Rao test, and the Wald test. At the stage of performance evaluation, we illustrate the detection performance of the proposed detectors in the presence of completely unknown interference (not constrained to lie in the above subspace). Numerical examples indicate that the proposed GLRT and Wald test can provide better detection performance than the existing detectors.
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http://dx.doi.org/10.3390/s22072430 | DOI Listing |
NPJ Antimicrob Resist
September 2025
Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Studying how antibacterials operate at subinhibitory concentrations reveals how they impede normal growth. While previous works demonstrated drugs can impact multiple aspects of growth, such as prolonging the doubling time or reducing the maximal bacterial load, a systematic understanding of this phenomenon is lacking. It remains unknown if common principles dictate how drugs interfere with growth.
View Article and Find Full Text PDFNucleic Acids Res
September 2025
Division of Chromatin Regulation, National Institute for Basic Biology, Okazaki 444-8585, Japan.
Methylation of histone H3 at lysine 9 (H3K9me), a hallmark of heterochromatin, is catalyzed by Clr4/Suv39. Clr4/Suv39 contains two conserved domains-an N-terminal chromodomain and a C-terminal catalytic domain-connected by an intrinsically disordered region (IDR). Several mechanisms have been proposed to regulate Clr4/Suv39 activity, but how it is regulated under physiological conditions remains largely unknown.
View Article and Find Full Text PDFMicrobiol Spectr
September 2025
Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, Missouri, USA.
Unlabelled: Zika virus (ZIKV) is the lone member of Flavivirus family known to cause congenital glaucoma following exposure. The molecular mechanisms of ZIKV-induced glaucoma remain elusive, with no known therapeutic modalities. Autophagy plays a dual role in viral infections and glaucoma pathogenesis.
View Article and Find Full Text PDFJ Bacteriol
September 2025
Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Essential genes are interesting in their own right and as potential antibiotic targets. To date, only one report has identified essential genes on a genome-wide scale in , a problematic pathogen for which treatment options are limited. That foundational study used large-scale transposon mutagenesis to identify 404 protein-encoding genes as likely to be essential for vegetative growth of the epidemic strain R20291.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
Jiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, Jiangsu, China; Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture and Rural Affairs, Sericultural Research Inst
The molecular mechanism of baculovirus infection is the basis of baculovirus wide application. Identifying and elucidating the functional genes of virus replication is the focus of research. Eukaryotic initiation factor 4E (eIF4E) is a key component of the translation initiation process to synthesize proteins required for replication.
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