BmeIF4E2 promotes AcMNPV infection in the silkworm, Bombyx mori, by direct interaction.

The molecular mechanism of baculovirus infection is the basis of baculovirus wide application. Identifying and elucidating the functional genes of virus replication is the focus of research. Eukaryotic initiation factor 4E (eIF4E) is a key component of the translation initiation process to synthesize proteins required for replication.

miR-6497-5p suppresses AcMNPV infection by targeting organic cation transport protein in silkworm, Bombyx mori.

Baculovirus is a multipurpose virus with a wide range of applications, such as protein expression, disease therapy, biocontrol, and so forth. It is of great significance to elucidate the mechanisms of their application as biopesticides, since insect resistance to viruses limits their application. Autographa californica nucleopolyhedrovirus (AcMNPV) is a representative species of α-baculovirus, and the silkworm is an ideal model organism for Lepidoptera.