Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: Due to its pivotal role in the modulation of immune and inflammatory responses, the gut microbiota has emerged as a key modulator of cancer treatment-induced gastrointestinal mucositis. However, it is not clear yet how it affects radiation therapy-induced oral mucositis (OM). As such, this study aimed to explore the gut microbiota's role in the pathogenesis of radiation-induced OM in rats.
Methods And Materials: Male Sprague Dawley rats were treated with 20 Gy x-ray radiation (Rx) delivered to the snout, with or without antibiotic-induced microbiota depletion (AIMD). OM severity was assessed, and tongue tissues were collected on day 9 and 15 postradiation for tissue injury and inflammatory markers assessment.
Results: AIMD+Rx had a significantly shorter duration of severe OM compared with Rx alone group. Macroscopically, the tongue ulcer-like area was smaller in AIMD+Rx compared with the Rx group. Microscopically, a smaller percentage of the mucosal ulcer was observed in the dorsal tongue of AIMD+Rx compared with the Rx group. AIMD+Rx also had significantly lower levels of interleukin 6, interleukin 1 beta, and toll like receptor 4 in the tongue tissues than the Rx group.
Conclusions: The gut microbiota plays a role in OM pathogenesis, mainly in the recovery phase, through the modulation of proinflammatory pathways. Future microbiota-targeted interventions may improve OM in clinical settings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijrobp.2022.03.036 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oligochitosan-Ameliorated Gut Microbiome and Metabolic Homeostasis in Hybrid Groupers (Epinephelus lanceolatu ♂ × Epinephelus fuscoguttatus ♀) Infected With Vibrio harveyi.
J Fish Dis
September 2025
Guangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong
Vibrio infections cause enteritis in grouper fish, leading to high mortality and stunted growth, which is a major challenge for aquaculture. Oligochitosans, marine prebiotics with bioactive properties, have proven their potential for growth promotion and immune regulation. However, the impacts of Vibrio harveyi on the gut microbiome of grouper fish and the potential of oligochitosans to modulate these effects remain poorly understood.
View Article and Find Full Text PDFEffects of metformin on gut microbiota and short/mediumchain fatty acids in highfat diet rats.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Laboratory Animal Science, Xiangya School of Medicine, Central South University, Changsha 410013, China.
Objectives: Recent evidence suggests that the gut may be a primary site of metformin action. However, studies on the effects of metformin on gut microbiota remain limited, and its impact on gut microbial metabolites such as short-/medium-chain fatty acids is unclear. This study aims to investigate the effects of metformin on gut microbiota, short-/medium-chain fatty acids, and associated metabolic benefits in high-fat diet rats.
View Article and Find Full Text PDFKefir Grains in Self-Assembled Nanofibrils: Structural Role and Nutritional Applications.
APMIS
September 2025
Department of Chemistry, PSGR Krishnammal College for Women, Coimbatore, Tamil Nadu, India.
Kefir grains offer numerous health benefits, including boosting the immune system, alleviating digestive issues, and enhancing antimicrobial activity. They are rich in beneficial probiotic bacteria that promote gut health and support a balanced intestinal microbiota. "Beta-lactoglobulin (β-lg), a well-known milk protein," is used to create nanofibril structures that can serve as scaffolds.
View Article and Find Full Text PDFFecal Microbiota Transplantation by Rectal Enema Improves Short-Term Insulin Resistance in Metabolic Syndrome: A Pilot Randomized Controlled Trial.
J Obes Metab Syndr
September 2025
Center of Excellence in Digestive diseases and Gastroenterology Unit, Department of Medicine, Thammasat University, Pathumthani, Thailand.
Background: The gut microbiota plays a vital role in various physiological processes, including metabolism. Fecal microbiota transplantation (FMT) involves transferring fecal matter from a healthy donor to rebalance a patient's intestinal dysbiosis. The impact of FMT on metabolic syndrome (MetS) is subject to debate.
View Article and Find Full Text PDFUncovering the Anti-Atherosclerotic Effect of Isoquercitrin via Microbiome Metabolic Modulation and Network Pharmacology.
J Agric Food Chem
September 2025
College of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi 030000, China.
Atherosclerosis (AS) is increasingly recognized as a disease influenced not only by lipid metabolism and inflammation but also by the gut microbiota and their bioactive metabolites. Isoquercitrin (ISO), a natural flavonoid with food-medicine homology, has shown promising antiatherosclerotic potential, yet its underlying mechanisms remain unclear. In this study, ISO administration significantly reduced plaque burden, improved lipid profiles, and restored gut microbial balance by enriching beneficial taxa, such as , , and .
View Article and Find Full Text PDF