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This randomized clinical trial investigates the effect of partial vs full disclosure of potential assignment to placebo on participant blinding, perceptions of group assignment, and clinical outcomes.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948530 | PMC |
http://dx.doi.org/10.1001/jamanetworkopen.2022.4050 | DOI Listing |
Retina
September 2025
Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 15, CH-3010.
Purpose: To evaluate inter-grader variability in posterior vitreous detachment (PVD) classification in patients with epiretinal membrane (ERM) and macular hole (MH) on spectral-domain optical coherence tomography (SD-OCT) and identify challenges in defining a reliable ground truth for artificial intelligence (AI)-based tools.
Methods: A total of 437 horizontal SD-OCT B-scans were retrospectively selected and independently annotated by six experienced ophthalmologists adopting four categories: 'full PVD', 'partial PVD', 'no PVD', and 'ungradable'. Inter-grader agreement was assessed using pairwise Cohen's kappa scores.
Cereb Cortex
August 2025
Faculty of Psychology and Education Science, Department of Psychology, University of Geneva, Chemin des Mines 9, Geneva, 1202, Switzerland.
Language learning and use relies on domain-specific, domain-general cognitive and sensory-motor functions. Using fMRI during story listening and behavioral tests, we investigated brain-behavior associations between linguistic and non-linguistic measures in individuals with varied multilingual experience and reading skills, including typical reading participants (TRs) and dyslexic readers (DRs). Partial Least Square Correlation revealed a main component linking cognitive, linguistic, and phonological measures to amodal/associative brain areas.
View Article and Find Full Text PDFBrief Bioinform
August 2025
School of Computer Science, Xi'an Polytechnic University, 710048, Xi'an, China.
Cancer, with its inherent heterogeneity, is commonly categorized into distinct subtypes based on unique traits, cellular origins, and molecular markers specific to each type. However, current studies primarily rely on complete multi-omics datasets for predicting cancer subtypes, often overlooking predictive performance in cases where some omics data may be missing and neglecting implicit relationships across multiple layers of omics data integration. This paper introduces Multi-Layer Matrix Factorization (MLMF), a novel approach for cancer subtyping that employs multi-omics data clustering.
View Article and Find Full Text PDFKnee Surg Sports Traumatol Arthrosc
September 2025
Orthopaedic Research Foundation of Western Australia, Perth, Western Australia, Australia.
Purpose: The purpose of the study was to identify the safety and effectiveness of an accelerated (AR) versus conservative (CR) rehabilitation regimen following surgical repair of proximal hamstring tendon avulsions.
Methods: This prospective randomized controlled trial (RCT) allocated patients undergoing proximal hamstring tendon repair to either a braced, partial weight-bearing rehabilitation regime (CR = 30) or an accelerated, unbraced regime, which permitted full weight-bearing as tolerated (AR = 27). Patients were evaluated pre-operatively and at 6 weeks, 3 and 6 months post-surgery, via patient-reported outcome measures (PROMs), patient satisfaction and global rating of change (GRC) scores.
PLoS One
September 2025
Facultad de Humanidades, Comunicación y Artes, Universidad Privada de Santa Cruz de la Sierra, Santa Cruz de la Sierra, Bolivia.
Objective: To examine the direct effect of purpose in life (PIL) on anxiety and its indirect effect through hope in a sample of university students from Ecuador, Bolivia, and Colombia, while assessing the cross-national measurement equivalence of the mediation model.
Method: A descriptive, correlational, and cross-sectional study was conducted using Structural Equation Modelling (SEM) to test mediation effects and Multigroup Confirmatory Factor Analysis (MG-CFA) to assess measurement invariance. The sample included 1,459 university students from Ecuador, Colombia, and Bolivia.