Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Double homeobox A pseudogene 8 (DUXAP8) is a known tumor promoter in several malignancies. Nonetheless, its function in colon cancer (CC) is indefinite. Herein, we explored the significance of DUXAP8 and its underlying mechanism in CC. Our data indicated that DUXAP8 was upregulated in CC, and it was related to advanced stages and lymph node metastases. Based on our Kaplan-Meier survival analysis, elevated DUXAP8 expression resulted in shorter patient overall survival (OS). Conversely, DUXAP8 silencing strongly suppressed cellular proliferation, migration and invasion . Based on our western blot analysis, DUXAP8 deficiency strongly inhibited the epithelial-mesenchymal transition (EMT) . Alternately, DUXAP8 overexpression accelerated cellular proliferation migration and invasion in CC. Finally, silencing DUXAP8 prevented tumorigenesis in a mouse xenograft model . Collectively, our results demonstrated that DUXAP8 regulates the occurrence and advancement of CC, and may serve as a regulatory hub for this disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161926 | PMC |
| http://dx.doi.org/10.1080/21655979.2022.2053802 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In Vitro Evaluation of the Effects of Multipoint Hyaluronic Acid-Based Intradermal Fillers on Skin Quality Using a Novel 3D Reconstructed Skin Aging Model.
J Cosmet Dermatol
September 2025
Laboratoires VIVACY, France.
Background: Superficial injection of hyaluronic acid (HA)-based gels is a widely used method to restore skin quality and achieve a more youthful appearance. While the clinical benefits of such procedures are well established, their biological mechanisms of action remain poorly understood.
Objective: This study aimed to evaluate the effectiveness of two cross-linked HA gels (IPN-12.
Viscoelastic time responses of polymeric cell substrates measured continuously from 0.1-5000 Hz in liquid by photothermal AFM nanorheology.
Nanoscale
September 2025
Department of Physics, University of Oxford, Parks Road, Oxford, OX1 3PU, UK.
The mechanical properties of the polymeric substrate or matrix where a cell grows affect cell behavior. Most studies have focused on relating elastic properties of polymeric substrates, which are time-independent, to cell behaviors. However, polymeric substrates and biological systems exhibit a time-dependent, often viscoelastic, mechanical response.
View Article and Find Full Text PDFCirc_0074158 and QKI6: A regulatory axis for PD-L1 ubiquitination and immune evasion in NSCLC.
Cancer Immunol Immunother
September 2025
Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, China.
Objective: CircRNAs are involved in cancer progression. However, their role in immune escape in non-small cell lung cancer (NSCLC) remains poorly understood.
Methods: This study employed RIP-seq for the targeted enrichment of circRNAs, followed by Western blotting and RT-qPCR to confirm their expression.
Antiemetic drug fosaprepitant exerts anti-tumor effects against NSCLC by targeting FAK to inhibit AKT and JNK/c-Jun pathways.
Acta Pharmacol Sin
September 2025
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Non-small cell lung cancer (NSCLC) is an aggressive malignancy with a poor prognosis. Abnormal expression of focal adhesion kinase (FAK) is closely linked to NSCLC progression, highlighting the need for effective FAK inhibitors in NSCLC treatment. In this study we conducted high-throughput virtual screening combined with cellular assays to identify potential FAK inhibitors for NSCLC treatment.
View Article and Find Full Text PDFThe peptide ENSG00000232259-ORF inhibits glioma cell proliferation and migration by promoting autophagy.
Brain Res
September 2025
Department of Pathology, Xinxiang Medical University, Xinxiang, China. Electronic address:
Glioma is a malignant brain tumor in which the lncRNA ENSG00000232259 is significantly upregulated. Bioinformatics predictions suggest that it may encode the polypeptide ENSG00000232259-ORF, but the biological function and mechanisms of this polypeptide in glioma remain unclear. Gene expression and correlation analyses were conducted using the GEPIA database, combined with GetORF to predict the polypeptide-coding potential, and Western blot was employed to validate the expression of ENSG00000232259-ORF.
View Article and Find Full Text PDF