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Background: Moderate hyperthermia is a potent and evidence-based radiosensitizer. Several indications are reimbursed for the combination of deep hyperthermia with radiotherapy (dHT+RT). We evaluated the current practice of dHT+RT in Switzerland.
Methods: All indications presented to the national hyperthermia tumor board for dHT between January 2017 and June 2021 were evaluated and treatment schedules were analyzed using descriptive statistics.
Results: Of 183 patients presented at the hyperthermia tumor board, 71.6% were accepted and 54.1% (99/183) finally received dHT. The most commonly reimbursed dHT indications were "local recurrence and compression" (20%), rectal (14.7%) and bladder (13.7%) cancer, respectively. For 25.3% of patients, an individual request for insurance cover was necessary. 47.4% of patients were treated with curative intent; 36.8% were in-house patients and 63.2% were referred from other hospitals.
Conclusions: Approximately two thirds of patients were referred for dHT+RT from external hospitals, indicating a general demand for dHT in Switzerland. The patterns of care were diverse with respect to treatment indication. To the best of our knowledge, this study shows for the first time the pattern of care in a national cohort treated with dHT+RT. This insight will serve as the basis for a national strategy to evaluate and expand the evidence for dHT.
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http://dx.doi.org/10.3390/cancers14051175 | DOI Listing |
J Colloid Interface Sci
September 2025
Institute of Biomedical Engineering, College of Medicine, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, PR China. Electronic address:
Pyroelectrodynamic therapy (PEDT) of tumors faces challenges due to its low electrocatalytic efficiency at mild temperature and the potential for off-target toxicity to healthy tissue. To overcome these issues, we have engineered pyroelectric nanoparticles (NPs) that feature a pH-triggered heterojunction structure and tumor-selective reactive oxidative species (ROS) production, faclitating synergistic PEDT and mild photothermal therapy (PTT). Herein, molybdenum trioxide (MoO) was deposited in-situ on the surface of tetragonal BaTiO (tBT) to create tBT@MO.
View Article and Find Full Text PDFNat Chem
September 2025
Department of Chemistry, University of Oxford, Oxford, UK.
The flexible and modular design of synthetic cells, comprising lipid vesicles capable of imitating the structure and function of living cells, facilitates their application as drug delivery devices. The ability to control the synthesis of biomolecules within synthetic cells using a tissue-penetrating stimulus opens up additional levels of functionality that has the potential to improve biological potency and circumvent drug leakage from preloaded vesicles. To this end, we have designed spherical nucleic acids comprising DNA promoter sequences decorating magnetic nanoparticle cores.
View Article and Find Full Text PDFAdv Healthc Mater
August 2025
Key Laboratory of Organosilicon Chemistry and Materials Technology of the Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Zhejiang, Hangzhou, 311121, P. R. China.
The integration of multimodal therapies into a single nanoplatform promises significant advances in precision oncology, yet structural instability, premature drug leakage, and insufficient immune activation remain key challenges. Herein, a supramolecular metallacycle-based nanoplatform (M2S-AD NPs) is engineered through coordination-driven self-assembly and β-cyclodextrin-mediated host-guest encapsulation. The metallacycle exhibits aggregation-induced emission (AIE) characteristics to amplify NIR-II fluorescence (1084 nm) for real-time tumor imaging and achieves a record-high photothermal conversion efficiency (42.
View Article and Find Full Text PDFAdv Mater
August 2025
Department of Biomedical Engineering and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Microrobots hold immense potential in biomedical applications, including drug delivery, disease diagnostics, and minimally invasive surgeries. However, two key challenges hinder their clinical translation: achieving scalable and precision fabrication, and enabling non-invasive imaging and tracking within deep biological tissues. Magnetic particle imaging (MPI), a cutting-edge imaging modality, addresses these challenges by detecting the magnetization of nanoparticles and visualizing superparamagnetic nanoparticles (SPIONs) with sub-millimeter resolution, free from interference by biological tissues.
View Article and Find Full Text PDFNanotechnology
August 2025
Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, 23284, United States of America.
Magnetic hyperthermia treatment (MHT) utilizes heat generated from magnetic nanoparticles under an alternating magnetic field for therapeutic applications. Gadolinium silicide (GdSi) has emerged as a promising MHT candidate. However, the impact of high-dose x-ray irradiation on its magnetic behavior remains uncertain.
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