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Brain cancer ranks tenth on the list of leading causes of death in both men and women. Biopsy is one of the most used methods for diagnosing cancer. However, the biopsy process is quite dangerous and take a long time to reach a decision. Furthermore, as the tumor size is rising quickly, non-invasive, automatic diagnostic equipment is required which can automatically detect the tumor and its stage precisely in a few seconds. In recent years, techniques based on Machine Learning and Deep Learning (DL) for detecting and classifying cancers has gained remarkable success in recent years. This paper suggested an ensemble method for detecting and classifying brain tumor and its stages using brain Magnetic Resonance Imaging (MRI). A modified InceptionResNetV2 pre-trained model is used for tumor detection from MRI image. After tumor detection, a combination of InceptionResNetV2 and Random Forest Tree (RFT) is used to determine the cancer stage, which includes glioma, meningioma, and pituitary cancer. The size of the dataset is small, so C-GAN (Cyclic Generative Adversarial Networks) is used to increase the dataset size. The experiment results demonstrate that the suggested tumor detection and tumor classification models achieve the accuracy of 99% and 98%, respectively.
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http://dx.doi.org/10.1007/s12539-022-00502-6 | DOI Listing |
Appl Biochem Biotechnol
September 2025
Operating Room, Shanghai Tianyou Hospital, No.528, Zhennan Road, Putuo District, Shanghai, 200331, China.
Gastric cancer (GC) is a malignant tumor originating from the epithelial cells of the gastric mucosa. The 5-methylcytosine (mC) modification refers to the addition of a methyl group to the fifth carbon atom of cytosine in RNA molecules. This study aimed to investigate the role of NOL1/NOP2/SUN domain (NSUN)6 in GC and its underlying molecular mechanisms.
View Article and Find Full Text PDFMol Cell Biochem
September 2025
Department of Laboratory Medicine, The People's Hospital of Zhongjiang, No. 96, Dabei Street, Kaijiang Town, Zhongjiang County, Deyang City, 618100, Sichuan Province, China.
5-methylcytosine (m5C) methylation is a post-transcriptional modification of RNAs, and its dysregulation plays pro-tumorigenic roles in lung adenocarcinoma (LUAD). Here, this study elucidated the mechanism of action of NSUN2, a major m5C methyltransferase, on LUAD progression. mRNA expression was analyzed by quantitative PCR.
View Article and Find Full Text PDFAnn Surg Oncol
September 2025
Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.
Background: The optimal number of examined lymph nodes (ELN) for accurate staging and prognosis for esophageal cancer patients receiving neoadjuvant therapy remains controversial. This study aimed to evaluate the impact of ELN count on pathologic staging and survival outcomes and to develop a predictive model for lymph node positivity in this patient population.
Methods: Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and a multicenter cohort.
Ann Surg Oncol
September 2025
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Background: Postoperative late recurrence (POLAR) after 2 years from the date of surgical resection of hepatocellular carcinoma (HCC) represents a unique surveillance and management challenge. Despite identified risk factors, individualized prediction tools to guide personalized surveillance strategies for recurrence remain scarce. The current study sought to develop a predictive model for late recurrence among patients undergoing HCC resection.
View Article and Find Full Text PDFAm J Clin Oncol
September 2025
Servicio de Oncología Médica HM CIOCC, Hospital Universitario HM Sanchinarro, Facultad HM de Ciencias de la Salud de la Universidad Camilo José Cela, Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain.
Objectives: To evaluate the association between the KRAS mutational load and the histologic tumor response in patients with resectable pancreatic ductal adenocarcinoma (PDAC) who received neoadjuvant treatment (NAC) with pegylated liposomal irinotecan in combination with oxaliplatin, 5-fluorouracil, and leucovorin (NALIRIFOX).
Methods: This was a multicenter, single-arm, interventional, open-label, phase 2 trial in patients 18 years or older who had histologically or cytologically confirmed PDAC and were candidates for surgery and received neoadjuvant NALIRIFOX. The primary outcome was determination of the association between the KRAS mutational load and the histologic tumor response after chemotherapy.