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http://dx.doi.org/10.1097/CM9.0000000000001553 | DOI Listing |
Front Nutr
August 2025
Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Background: Voghera pepper (VP) extracts were demonstrated to have anti-oxidant ability in several cell types.
Purpose: This study aimed to assess whether VP-extracts could lower oxidative stress and modulate thyroid cancer (TC) cells behavior .
Methods: Extracts were analyzed using the LC-DAD-MS system.
Front Oncol
August 2025
Department of Pathology, Institute of Clinical Pathology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Despite the generally favorable prognosis of differentiated thyroid carcinoma (DTC) following surgery and radioactive iodine (RAI) therapy, approximately 10% of cases eventually develop resistance to RAI. This condition, known as radioiodine-refractory differentiated thyroid carcinoma (RAIR-DTC), is associated with a poor prognosis, with a 10-year survival rate of only 10% from the time of metastasis detection. The limited availability of safe and effective alternative treatments poses a significant challenge to clinical management.
View Article and Find Full Text PDFJ Inflamm Res
September 2025
The Second Clinical College of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People's Republic of China.
Purpose: Autoimmune thyroiditis (AIT) is the most common organ-specific autoimmune disease, and its pathogenesis is closely related to the inflammatory microenvironment driven by immune cell penetration. The role of the newly proposed concept of PANoptosis in immune-related diseases is gradually being revealed. However, there is currently a lack of reports on PANoptosis in AIT.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany.
Introduction: The prognosis of anaplastic thyroid carcinoma (ATC) remains poor. Mutation-based targeted therapies and immune checkpoint inhibitors (ICI) have gained increasing importance in the treatment of advanced tumor stages. This study aimed to investigate whether mutation-based neoadjuvant therapy can convert an initially unresectable tumor into a resectable state, optimizing local tumor control and prolonging overall survival.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Introduction: Anti-thyroid peroxidase antibodies (TPO-Ab) are detectable in almost all patients with autoimmune thyroid disease or Hashimoto's thyroiditis (HT) but may also be present in healthy individuals. HT affects women to a greater extent than men and can lead to overt hypothyroidism, which may increase the risk of miscarriage. There are no local data available on the prevalence of TPO-Ab among healthy women in the United Arab Emirates.
View Article and Find Full Text PDF