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Skin tethering (ST) is regarded as a classical clinical feature of breast cancer. In many cases, ST is not evident on inspection, with the arm raised and skin pinching over the lump. We have observed that pushing the lump in one or another direction may elicit skin dimpling that was not otherwise evident. In these cases, there is normal fat, grossly and histologically, between the tumor and the skin. Thus, the dimpling is not due to cutaneous infiltration. We believe that it is caused by tumor involvement of the ligaments of Cooper and present suggestions as to why it might be so. It may be that this is very early involvement of these ligaments, long before ST becomes very obvious. We report our experience with six such cases.
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http://dx.doi.org/10.7759/cureus.20471 | DOI Listing |
Urol J
September 2025
Gazi University, Faculty of Medicine, Department of Pediatric Surgery, Ankara, Turkey.
Purpose: To review the current literature on dorsal penile curvature (DPC) in children, including its etiology, diagnosis, and principles of treatment.
Materials And Methods: A literature review was conducted on DPC in children, focusing on its etiology (e.g.
Sci Adv
September 2025
Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA.
Assessing the mechanical properties of soft tissues holds broad clinical relevance. Advances in flexible electronics offer possibilities for wearable monitoring of tissue stiffness. However, existing technologies often rely on tethered setups or require frequent calibration, restricting their use in ambulatory environments.
View Article and Find Full Text PDFAesthetic Plast Surg
August 2025
Department of Craniomaxillofacial Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No 33, Ba-Da-Chu Road, Shi Jing Shan District, Beijing, 100144, People's Republic of China.
Tear trough correction poses unique challenges due to complex anatomy and ethnic variations. While immediate outcomes do not represent long-term efficacy, they are crucial for patient satisfaction in minimally invasive aesthetic procedures. In our cohort, no significant complications were observed, and patient satisfaction remained at 6-month follow-up.
View Article and Find Full Text PDFCurr Med Chem
August 2025
Natural and Medical Sciences Research Center, University of Nizwa, , Birkat Al Mauz, Nizwa, PO Box 33, 616, Oman.
Introduction: Tyrosinase, a copper-containing enzyme, is responsible for melanin production, and its overactivity can lead to hyperpigmentation.
Methods: This study aimed to evaluate triazolothiadiazoles (3a-h, 4a-f) and triazolothiadiazines (5a-h) against human and mushroom tyrosinase isozymes.
Results: Several derivatives, such as 3a-3b, 3d, 4c-4f, 5d, and 5e, were identified as potent and selective inhibitors of mushroom tyrosinase, with IC50 values ranging from 1.
Arch Pharm (Weinheim)
July 2025
University Institute of Pharma Sciences, Chandigarh University, Mohali, India.
Inspired by the anti-breast cancer and anti-tubulin potential of coumarin, indole, chalcone, and isatin moieties, a new series of triazole-tethered coumarin-fused chalcone and isatin hybrids were designed, synthesized, and evaluated for their anti-breast cancer activities. Among the series of hybrid compounds, JKUB2 showed the strongest activity against MCF-7 breast cancer cells with an IC value of 1.28 µM.
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