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Scutellariae Radix is a commonly used Chinese medicinal first recorded in the Shennong's Classic of Materia Medica. In the ancient books of traditional Chinese medicine(TCM), Scutellariae Radix is used in two specifications, solid one(Ziqin) and hollow one(Kuqin). In the current rules and regulations of Chinese medicine, Scutellariae Radix is used without the specific requirements for the specifications applied. To clarify the evolution of Scutellariae Radix specifications and analyze the current specifications of Scutellariae Radix pieces, the present study reviews the Scutellariae Radix from ancient literature, modern rules and regulations, and differences between Ziqin and Kuqin in composition, efficacy, and transformation mechanism. According to the research on ancient books, Kuqin is effective in clearing the fire of the upper energizer, and Ziqin in purging the heat of the lower energizer. Modern studies have revealed that Kuqin and Ziqin are significantly different in chemical components, and Ziqin and Kuqin target the colon and lung, respectively, which are consistent with the relevant records in ancient books. The review study suggests that the two specifications of Scutellariae Radix are reasonable since they can facilitate the precise treatment of Scutellariae Radix.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20210311.302 | DOI Listing |
Front Microbiol
August 2025
Institute of Animal Science, Ningxia Academy of Agriculture and Forestry, Yinchuan, Ningxia, China.
Introduction: Inflammation and oxidative stress can seriously endanger the health and growth of beef cattle. Georgi (SB) has significant anti-inflammatory and antioxidative effects. However, studies on the application of SB stems and leaves as roughage in animal husbandry are limited.
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August 2025
School of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.
Ethnopharmacological Relevance: Baicalin, an extract derived from the dried root of Scutellaria baicalensis Georgi (Huang Qin), has demonstrated neuroprotective properties. Nonetheless, the safety profile of baicalin has not yet been fully elucidated.
Aim Of The Study: The objective was to characterize the acute and subacute toxicity profiles of baicalin across various organ systems, thereby establishing safe therapeutic windows for its clinical application in the treatment of chronic neurodegenerative disorders.
Clin Transl Oncol
September 2025
Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Purpose: Oroxylin A (OA) is a flavonoid, obtained from the root of Scutellaria baicalensis Georgi which is a traditional Chinese herbal, with antitumor and other pharmacological activities. OA tablets are an innovative drug, and a formal single ascending and multiple dose pharmacokinetic (PK) trial was conducted in humans to evaluate the required to determine the safety and tolerability of OA as well as the effect of food on its PK parameters profile.
Methods: This clinical study consisted of three parts: single ascending dose (400[n = 3], 800, 1600 and 2400 mg OA [n = 8/group] and placebo [n = 6]), multiple dose (1600 or 2400 mg OA [n = 8 / group] and placebo [n = 4] once daily), and food effects (1600 mg OA single dose [n = 12]).
Prev Nutr Food Sci
August 2025
College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 61186, Korea.
This study developed an effective combination of and (SNE) and evaluated its anti-inflammatory and anti-hyperuricemic effects under conditions. First, the effect of SNE was tested on xanthine oxidase (XOD) activity. To investigate the anti-inflammatory effect of SNE, nitric oxide (NO) production was detected by Griess assay, and proinflammatory cytokines were measured by enzyme-linked immunosorbent assay in RAW264.
View Article and Find Full Text PDFToxicol Rep
December 2025
Department of Anatomy, Faculty of Biomedical Sciences, College of Medicine, Kampala International University, Uganda.
Background: Methylparaben is a commonly used preservative in the cosmetics, pharmaceutical, and food industries, valued for its antibacterial and antifungal effects. Numerous in vitro and in vivo studies have investigated its adverse effects on sperm count, testosterone levels, and reproductive organ weight. Baicalin, which comes from the dried roots of the plant Scutellaria baicalensis Georgi, is a natural compound that may have various health benefits, such as reducing fibrosis, itching, bacteria, oxidative stress, inflammation, and cancer.
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