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A Dual-Target Real-time PCR for proactive detection of Mpox variants.
J Virol Methods
September 2025
British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:
In 2022, cases of Monkeypox virus (MPXV) in California contained a mutation in the TNF receptor gene (GR2G) that rendered the virus undetectable using a widely adopted public health diagnostic qPCR assay. This underscored the need for a dual-target PCR approach and prompted validation of a second target by the BCCDC Public Health Laboratory. In addition to the GR2G target validated in the original qPCR assay (and duplexed with the endogenous target human β-globin (HBG)), GP113 (OPG128) was identified and validated using both clinical samples and MPXV DNA controls.
View Article and Find Full Text PDFAdenoviral Retinitis: A Rare Case Presentation of a Common Virus.
Ocul Immunol Inflamm
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Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
Purpose: To report a rare case of bilateral necrotising retinitis caused by a potentially novel human adenovirus D (HAdV-D) in a post-bone marrow transplant patient and to highlight the diagnostic challenges and therapeutic role of intravenous cidofovir, alongside a review of previously reported cases of human adenovirus (HAdV) retinitis.
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The Role of Viral Infections in the Immunopathogenesis of Type 1 Diabetes Mellitus: A Narrative Review.
Biology (Basel)
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Department of Laboratory Haematology, Metaxas Anticancer Memorial Hospital, 18537 Pireas, Greece.
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disorder characterized by the destruction of insulin-producing pancreatic beta cells, resulting in lifelong insulin dependence. While genetic susceptibility-particularly human leukocyte antigen (HLA) class II alleles-is a major risk factor, accumulating evidence implicates viral infections as potential environmental triggers in disease onset and progression. This narrative review synthesizes current findings on the role of viral pathogens in T1DM pathogenesis.
View Article and Find Full Text PDFSDS-EDTA-treated chromatography paper strips for sampling and transportation of monkeypox virus, varicella zoster virus and herpes simplex 1 and 2 viruses.
Virol J
September 2025
Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, KU Leuven, Leuven, 3000, Belgium.
Mpox is a viral zoonotic disease characterized by flu-like symptoms followed by rash, which can be difficult to distinguish from other rash-presenting infections. Laboratory diagnosis is essential for confirming monkeypox virus (MPXV) infection; However, challenges in specimen transport and storage in endemic regions, especially in rural areas with limited infrastructure, hinder timely diagnosis. This study evaluates the use of SDS-EDTA-treated chromatography paper strips for testing different viral dilutions of MPXV, varicella-zoster virus (VZV), herpes simplex viruses 1 (HSV-1) and 2 (HSV-2) under different storage durations and temperatures.
View Article and Find Full Text PDFVirus in infectious uveitis: bibliometric analysis and a clinical study.
Front Microbiol
August 2025
Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Introduction: In recent years, advancements in detection technology have led to increased research interest in viral uveitis.
Methods: This study conducted a comprehensive analysis, comprising a bibliometric examination of literature on virus and infectious uveitis and a retrospective study focusing on infectious uveitis. The bibliometric analysis aimed to elucidate past and emerging trends in this field over several decades.