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In light of the "replication crisis," some advocate for stricter standards and greater transparency in research methods. These efforts push toward a data analysis approach called "confirmatory data analysis" (CDA; see Wagenmakers et al., 2012). However, some (e.g., Baumeister, 2016; Goldin-Meadow, 2016) suggest that emphasizing CDA may restrict creativity and discovery. These scholars argued (sometimes inadvertently) for greater freedom to pursue "exploratory data analysis" (EDA; see Tukey, 1977). Ironically and unfortunately, many who push against stricter CDA standards do not realize EDA exists, or misunderstand the philosophy and proper tools for exploration. In this article, the meaning, tools, philosophy, and ethics associated with EDA, CDA, and a relatively unknown but important approach called "rough CDA" are clarified. Important distinctions are developed between EDA/rough CDA/CDA and other (some problematic) analysis activities including p-hacking, HARKing, and data mining, which are situated in a (graphical) framework that clarifies relationships and ethical boundaries with each. In short, the proper data analytic approach depends on (a) intentions and (b) transparency. Most psychological research is not at a maturity level to justify CDA; researchers have historically used tools mismatched to their research agenda. In the conclusion, recommendations are presented about how these typologies can be integrated into graduate training programs and how a cumulative research program can help psychology move beyond the replication crisis. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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http://dx.doi.org/10.1037/amp0000886 | DOI Listing |
Biochem Biophys Res Commun
September 2025
Selcuk University, Faculty of Medicine, Department of Medical Biochemistry, Konya, Turkey. Electronic address:
This study investigates the cytotoxic and biochemical effects of PEGylated graphene oxide sol-gel (SJ-go) nanoparticles, curcumin, and quercetin on BEAS-2B human bronchial epithelial. In this work, a new graphene oxide nanocomposite (SJ-go) was produced using the sol-gel method through a one-step reaction. These hybrid sol-gel systems include graphite, triethyl orthosilicate (TEOS), and polyethylene glycol (PEG) having a molecular weight of 8000 g/mol.
View Article and Find Full Text PDFEur J Radiol
September 2025
School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:
Purpose: To explored key angiographic markers associated with headache risk in patients with unruptured brain arteriovenous malformations (BAVMs).
Methods: This retrospective study included patients with unruptured, supratentorial BAVMs without prior interventions who underwent digital subtraction angiography between January 2011 and January 2024. The patients were stratified into headache and nonheadache groups on the basis of symptoms at initial presentation.
Clin Neurol Neurosurg
September 2025
Neurovascular Research Unit, Department of Neurology, Copenhagen, University Hospital - Herlev and Gentofte, Herlev, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Brain, and Spinal Cord Injury, Copenhagen University Hospital - Rigshospitalet,
Objective: Severity and outcome of stroke may be associated with a concomitant or subsequent inflammatory response. C-reactive protein (CRP) may correlate with length of stay (LOS) in hospital, indicating increased complexity of stroke patients with an ongoing inflammatory reaction upon admission.
Methods: This retrospective cross-sectional study used data from admissions to the non-comprehensive Stroke Unit, which receives patients ineligible for revascularization therapy at Herlev-Gentofte hospital, in 2019 and 2020.
Soc Sci Med
August 2025
Centre for Gender Research, Uppsala University, Sweden. Electronic address:
The use of donor eggs, sperm and embryos in medically assisted reproduction (MAR) provide new possibilities for reproductive assistance and family-making. In clinical practice, it also brings to light questions of responsibility and ethical conduct. Despite this, fertility practitioners' reasoning in clinical decision-making remains surprisingly understudied.
View Article and Find Full Text PDFMar Pollut Bull
September 2025
Florida International University, Civil and Environmental Engineering, 10555 West Flagler Street, Engineering Center, Miami, Florida 33174, USA. Electronic address:
Marine ecosystems are increasingly threatened by anthropogenic pollutants, including plastics, persistent organic pollutants, heavy metals, oil, and emerging contaminants. This meta-analysis examined the accumulation patterns of five major contaminants-mercury (Hg), polychlorinated biphenyls (PCBs), microplastics, per- and polyfluoroalkyl substances (PFAS), and polycyclic aromatic hydrocarbons (PAHs)-in relation to trophic level and lifespan across marine species. Data synthesis revealed distinct differences in bioaccumulation and biomagnification between legacy and emerging contaminants.
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