Two new lanostane-type triterpenoids from the fungus sp. TJ403-rc01.

Nat Prod Res

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Published: April 2023


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Article Abstract

The endophytic fungus sp. TJ403-rc01 (Dematiaceae) isolated from the leaves of Jacq. (Rosaceae) was cultivated on rice medium and chemically investigated, affording two new lanostane-type triterpenoids, namely pericinones A and B ( and ). Their structures were determined mainly by 1 D and 2 D NMR and HRESIMS data. Notably, it is the first report of lanostane-type triterpenoids from species of . Compounds and showed moderate anti-inflammatory activity against the NO production with IC values of 24.12 ± 0.73 and 11.38 ± 1.56 M, respectively.

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http://dx.doi.org/10.1080/14786419.2021.1998046DOI Listing

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