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The endophytic fungus sp. TJ403-rc01 (Dematiaceae) isolated from the leaves of Jacq. (Rosaceae) was cultivated on rice medium and chemically investigated, affording two new lanostane-type triterpenoids, namely pericinones A and B ( and ). Their structures were determined mainly by 1 D and 2 D NMR and HRESIMS data. Notably, it is the first report of lanostane-type triterpenoids from species of . Compounds and showed moderate anti-inflammatory activity against the NO production with IC values of 24.12 ± 0.73 and 11.38 ± 1.56 M, respectively.
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http://dx.doi.org/10.1080/14786419.2021.1998046 | DOI Listing |
Org Lett
September 2025
Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, P. R. China.
Chizhiaroterpenoids A-C (-), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 (), 6/6/6/6/7 (), and 6/6/6/5/6 () ring systems, were isolated from . Their biosynthetic pathways were proposed. and suppressed lipopolysaccharide-induced inflammation in BV2 cells, restored BDNF levels, and alleviated depression-like behaviors in mice.
View Article and Find Full Text PDFACS Omega
June 2025
College of Bioengineering, Tianjin University of Science and Technology, Tianjin 300457, China.
Guided by the MS/MS metabolome-based molecular networking, 50 compounds, including 18 new triterpenoid metabolites (ganoleucocontins A-R, ), were obtained from Ganoderma leucocontextum. The chemical structures of these novel metabolites were determined based on comprehensive spectroscopic methods and chemical derivation. Compounds , and represent a new class of triterpenoid dimers linked by 3-hydroxy-3-methylglutaryl (HMG), which were reported for the first time.
View Article and Find Full Text PDFPhytochemistry
October 2025
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; School of Pharmacy, Fudan University, Shanghai, 201203,
Two undescribed protostane-type triterpenoids (1-2), and nine undescribed lanostane-type triterpenoids (3-11), along with nine known compounds (12-20) were isolated from the stems of Kadsura coccinea. Their chemical structures were elucidated by extensive spectroscopic analyses, Mosher's method, X-ray crystallography, and electronic circular dichroism calculations. Kadcoccinoid A (1) possesses an undescribed 6/6/8-fused carbocyclic core containing a rare bicyclo [4.
View Article and Find Full Text PDFPhytochemistry
October 2025
Chulabhorn Research Institute, Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok, 10210, Thailand; Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand. Electronic address:
Five previously undescribed lanostane-type triterpenes, astraeusols A-E (1-5), along with astraeusin M (6), astrasiate (7), astraeusin A (8), artabotryol A (9), artabotryol B (10), artabotryol C2 (11), cerevisterol (12), 6-epi-cerevisterol (13), and linoleic acid (14), were isolated from the fruiting bodies of the Thai wild edible mushroom Astraeus asiaticus. Astraeusols D (4) and E (5) were identified as lanostane triterpenes linked to phenylethylamine through amide linkages for the first time from a natural source. The configuration at C-25 of the original structure of artabotryol C2 (11) was revised from 25R to 25S.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
March 2025
Zhejiang Key Laboratory of Plant Secondary Metabolism and Regulation, College of Life Science and Medicine, Zhejiang Sci-Tech University Hangzhou 310018, China.
Ganoderic acid is a class of lanostane-type triterpenoids found in Ganoderma species, and is one of the most important pharmacologically active components in G. lucidum, exhibiting antioxidant, anti-neuropsychiatric, anti-tumor, and immune-enhancing properties. The content of ganoderic acid in G.
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