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Article Abstract
Purpose: The aim of this study was to investigate the effects of end-tidal carbon dioxide tension (ETCO) changes during remifentanil infusion on mandibular bone marrow tissue blood flow (BBF), masseter muscle tissue blood flow (MBF), mandibular bone marrow tissue oxygen tension (PbO) and masseter muscle tissue oxygen tension (PmO) in rabbits.
Methods: Ten male tracheotomized Japan White rabbits were anesthetized and ventilated with sevoflurane. ETCO was adjusted to 30 mmHg. After baseline measurement, CO was added to the inhaled air, and ETCO was increased to 40 and 60 mmHg. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), BBF, MBF, PbO, and PmO were recorded with and without remifentanil infusion at 0.4 µg/kg/min.
Results: Two-way repeated measures analysis of variance showed no interaction between ETCO and remifentanil in all variables. Remifentanil infusion produced decreases in HR, SBP, MAP, BBF and MBF compared with those without remifentanil infusion, while it did not affect DBP, PbO and PmO. Elevation of ETCO from 30 to 60 mmHg produced decreases in HR and MBF, and increases in SBP, DBP, MAP and BBF, while it did not affect PbO and PmO.
Conclusion: PbO and PmO remained unchanged despite changes in BBF and MBF during ETCO change with or without remifentanil infusion.
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| http://dx.doi.org/10.1007/s00540-021-03006-7 | DOI Listing |
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