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Background: The optimal treatment of Pauwels type III femoral neck fracture (FNF) in young patients remains a worldwide challenge in orthopedic surgery.
Methods: Finite element models of four internal fixations were developed to treat Pauwels type III FNF: a: the traditional inverted triangular parallel cannulated screw (PCS) model, b: the F-technique cannulated screw model, c: the modified F-technique cannulated screw model using a fully threaded screw instead of a partially threaded distally, d: the dynamic hip screw coupled with derotational screw (DHS + DS) model. Under the same conditions, finite element analyses were carried out to compare the displacement and von Mises stress distribution of four internal fixations and femurs, the maximum crack distances of the fracture surfaces, Z axis displacements of four models as well as the stress distribution in the subtrochanteric region.
Results: The modified F-technique configuration resulted in a more stable fixation as compared to the other three configurations, with respect to the maximum displacement and stress peaks of femur and internal fixations, the maximum crack distances of the fracture surfaces, Z axis displacements of four configurations as well as the stress distribution in the subtrochanteric region.
Conclusions: Our results suggested that modified F-technique configuration show a better performance in resisting shearing and rotational forces in treating Pauwels type III FNF compared to those using traditional inverted triangular PCS, the F-technique configuration or DHS + DS, providing a new choice for the treatment of FNFs.
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http://dx.doi.org/10.1186/s12891-021-04638-2 | DOI Listing |
Front Bioeng Biotechnol
August 2025
Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Introduction: Ipsilateral femoral neck and shaft fractures (IFN-SFs) caused by high-energy trauma pose a significant risk of complications related to bone healing. Prompt identification of fracture types and maintenance of fracture fixation stability can mitigate this risk. This study employed finite element analysis to evaluate biomechanical parameters for the stability of fixation in IFN-SFs and quantify differences in biomechanical stability among various fracture types.
View Article and Find Full Text PDFFront Immunol
August 2025
Department of Diagnostic Sciences, Ghent University and Ghent University Hospital, Ghent, Belgium.
Introduction: The Gardasil-4 vaccine targets HPV types 6, 11, 16 and 18 and is formulated with amorphous alum. Cervarix targets HPV types 16 and 18 using AS04 (Al(OH)3 + TLR4 agonist MPL) to enhance immune response. Cervarix elicits higher cross-protection against other high-risk HPV types, likely mediated by AS04.
View Article and Find Full Text PDFAm J Transl Res
June 2025
Intensive Care Unit, Beilun District People's Hospital Ningbo, Zhejiang, China.
Objectives: This study proposed a novel fixation method - femoral calcar double-supported screw fixation (FCDSF) - and evaluated its biomechanical performance. The fixation's mechanical properties were assessed and compared with those of inverted triangular parallel cannulated screws (3CS) and biplane double-supported screw fixation (BDSF) for Pauwels type III femoral neck fractures (FNFs).
Methods: Fifty-four synthetic femur models were allocated into three reduction groups simulating positive buttress, anatomical reduction, and negative buttress conditions.
BMC Musculoskelet Disord
July 2025
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
Objectives: The purpose of this study was to compare the efficacy of femoral neck system (FNS) and cannulated screws with a medial plate (CSMP) for Pauwels type III femoral neck fractures in young adults.
Methods: In this retrospective analysis, 70 patients aged 18–65 with Pauwels type III femoral neck fractures were divided into two groups according to internal fixation: 37 in the FNS group and 33 in the CSMP group. Postoperative complications and functional outcomes were mainly studied.
Biol Methods Protoc
June 2025
Molecular, Structural and Translational Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Proteins are essential for life in all organisms: they mediate cell signaling and cell division and provide structure/motility to cells and tissues. All proteins are synthesized on cytoplasmic ribosomes as unfolded precursors that need to find their correct location in the compartmentalized cell. In eukaryotes, ∼30% of the proteome is translocated across or integrated into the endoplasmic reticulum (ER) membrane, a process mostly mediated by the heterotrimeric Sec61 complex that spans the ER membrane.
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