Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Increasing transmission of SARS-CoV-2 infection in successive waves may strain the capacity of laboratories performing molecular diagnostic testing. Alternative testing approaches may offer additional diagnostic capacity. A high throughput chemiluminescent antigen assay (Ortho VITROS SARS-CoV-2 antigen test) was evaluated using both an inactivated virus preparation and prospective clinical samples (nasopharyngeal swabs in virus transport medium). The limit of detection of the assay was approximately 0.5 TCID/ml, equivalent to a Ct value of 33. The assay was linear over a wide range. When 528 clinical samples were tested with the antigen assay, the sensitivity was 84.2% and the specificity was 100% (positive predictive value 100% and negative predictive value 97.7%). High volume antigen tests might be used to supplement molecular diagnostic testing capacity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327635 | PMC |
| http://dx.doi.org/10.1016/j.jcv.2021.104938 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Improved local control using higher dose SBRT in metastatic sarcoma patients.
Radiat Oncol
September 2025
Department of Breast Sarcoma and Endocrine Tumors, Karolinska University Hospital, Stockholm, Sweden.
Background: Stereotactic Body Radiotherapy (SBRT) has been proven to be a safe and effective alternative to surgery in patients with metastatic primary sarcoma. However, data describing tumor response in relation to the given radiotherapy dose is lacking. Therefore, this study aims at analyzing efficacy and dose-response relationship in a retrospective cohort.
View Article and Find Full Text PDFHigh-resolution anorectal manometry profile in patients with chronic constipation versus control.
Indian J Gastroenterol
September 2025
Department of Gastroenterology, Topiwala National Medical College and Bai Yamunabai Laxmanrao Nair Charitable Hospital, Mumbai, 400 008, India.
Background And Aims: Studies comparing chronic constipation (CC) and asymptomatic subjects are lacking in our population. This study aimed to compare the high-resolution anorectal manometry (HRAM) profiles of patients with CC and healthy volunteers (HV), as well as patients with functional defecation disorders (FDD) and those without in the constipation group.
Methods: This retrospective comparative study included patients with CC who underwent HRAM and a balloon expulsion test (BET).
Long-term outcomes and quality of life after repair of benign biliary stricture of post-cholecystectomy bile duct injury.
Indian J Gastroenterol
September 2025
Department of GI Surgery, HPB and Liver Transplantation, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
Introduction: Bile duct injury (BDI) is a potentially devastating complication of cholecystectomy. Although the repair may be successful, patients often experience a decline in their quality of life (QoL). However, there is a paucity of data regarding the factors influencing long-term outcomes and QOL in these patients.
View Article and Find Full Text PDFCentral Hepatectomy as an Alternative: A Comparative Study with Conventional Major Hepatectomy for Perihilar Cholangiocarcinoma.
Ann Surg Oncol
September 2025
Department of Hepatobiliary-Pancreatic Surgery, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Background: Right-sided hepatectomy (RH) is the standard surgical approach for perihilar cholangiocarcinoma (PHC) due to anatomical considerations but is associated with a high risk of post-hepatectomy liver failure (PHLF). Left-sided hepatectomy (LH) and central hepatectomy (CH) have been proposed as alternative strategies to preserve liver function, but the feasibility and outcomes of CH have not been sufficiently investigated. CH allows for greater preservation of liver parenchyma, potentially reducing the risk of PHLF.
View Article and Find Full Text PDFRobotic total hip and knee arthroplasty: economic impact and workflow efficiency.
J Robot Surg
September 2025
Department of Orthopedic Surgery, Orthopedic and Rheumatology Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, A4144195, USA.
Robotic-assisted total joint arthroplasty (RA-TJA) is projected to account for 70% of all arthroplasties by 2030, yet its economic value and operational efficiency have yet to be thoroughly synthesized. While early literature emphasized technical precision, evolving payment models and implementation costs have shifted focus toward cost-effectiveness and workflow integration. To evaluate the economic and institutional viability of RA-TJA by synthesizing available evidence on capital costs, perioperative expenses, learning curves, throughput, and long-term adoption trends.
View Article and Find Full Text PDF