Bioinformatics Analysis of Expression Profiles and Prognostic Values of the Signal Transducer and Activator of Transcription Family Genes in Glioma.

Signal transducer and activator of transcription () family genes-of which there are seven members: , and -have been associated with the progression of multiple cancers. However, their prognostic values in glioma remain unclear. In this study, we systematically investigated the expression, the prognostic value, and the potential mechanism of the family genes in glioma. The expression of 1/2/3/5A/6 members were significantly higher and positively correlated with mutations, while the expression of was lower and negatively correlated with mutations in glioma. Survival analysis indicated that the upregulation of and downregulation of expression was associated with poorer overall survival in glioma. Joint effects analysis of expression suggested that the prognostic value of the group was more significant than that of each individual gene. Thus, we constructed a risk score model to predict the prognosis of glioma. The receiver operating characteristic curve and calibration curves showed good performance as prognostic indicators in both TCGA (The Cancer Genome Atlas) and the CGGA (Chinese Glioma Genome Atlas) databases. Furthermore, we analyzed the correlation between expression with immune infiltration in glioma. The Protein-protein interaction network and enrichment analysis showed that members and co-expressed genes mainly participated in signal transduction activity, Hepatitis B, the Jak-STAT signaling pathway, transcription factor activity, sequence-specific DNA binding, and the cytokine-mediated signaling pathway in glioma. In summary, our study analyzed the expression, prognostic values, and biological roles of the gene family members in glioma, based on which we developed a new risk score model to predict the prognosis of glioma more precisely.