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Objective: The present study aims to observe the optic nerve fiber layer thickness and blood flow density in the papillary area and investigate the effects of axial length (AL) and the refractive state of the optic papilla blood flow density in children with different refractive conditions.
Methods: The present study was a clinical control study. The right eyes of 204 minors aged 6-17 years were studied. The eyes were divided into four groups according to myopic refractive states. OCTA analyzed the data to compare the radial peripapillary capillary (RPC) density and the difference in the retinal nerve fiber layer (RNFL) thickness adjacent to the optic papilla between the four refraction groups.
Results: The intra-optic disc blood flow density was significantly and negatively correlated with the AL and was negatively correlated with the AL in the inferior temporal quadrants. The RNFL in the superior, nasal, and inferior quadrants was negatively correlated with the AL. The RNFL in the temporal quadrant was positively correlated with the AL.
Conclusion: Our present study revealed that aAs myopia increased and the AL grew in children, the blood density of the entire image of the optic papilla, in the optic disc, and the retinal capillaries in the inferior parapapillary and temporal quadrant would change significantly. With increasing AL, a significant decrease in the intra-disc and para-disc RNFL was observed in the superior, nasal, and inferior quadrants, while a substantial increase in RNFL was observed in the temporal quadrant.
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http://dx.doi.org/10.2147/IJGM.S317476 | DOI Listing |
CNS Neurosci Ther
September 2025
Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Aims: Sustained neuroinflammation following ischemic stroke impedes post-injury tissue repairment and neurological functional recovery. Developing innovative therapeutic strategies that simultaneously suppress detrimental inflammatory cascades and facilitate neurorestorative processes is critical for improving long-term rehabilitation outcomes.
Methods: We employed a microglia depletion-repopulation paradigm by administering PLX5622 for 7 days post-ischemia; followed by a 7-day withdrawal period to allow microglia repopulation.
Magn Reson Med
September 2025
Department of Biomedical Engineering, University of California, Davis, Davis, California, USA.
Purpose: This study sought to determine the intrasession repeatability of the diffusion-weighted (DW) arterial spin labeling (ASL) sequence at different postlabel delays (PLDs).
Methods: We first performed numerical simulations to study the accuracy of the two-compartment water exchange rate (Kw) fitting model with added Gaussian noise for DW PLDs at 1500, 1800, and 2100 ms. Ten young, healthy participants then underwent a structural T scan and two intrasession in vivo DW ASL scans at each PLD on a 3T MRI.
Abnormal immune responses are common clinical features in septic patients. γδ T cells, as innate immune cells, play an important role in host defense, immune surveillance and homeostasis. However, the immune characteristics of γδ T cells in pediatric sepsis remains remain poorly understood.
View Article and Find Full Text PDFBackground: Space exploration has progressed significantly, with increased human presence in orbit, the development of space stations, and the planning of increasingly prolonged missions. However, the space environment poses substantial physiological challenges, particularly for the cardiovascular system. According to NASA's Human Research Program, the five primary risks associated with human spaceflight are: (1) microgravity, (2) ionizing cosmic radiation, (3) isolation and confinement, (4) closed environmental systems, and (5) the great distance from Earth.
View Article and Find Full Text PDFMagn Reson Med
September 2025
Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Purpose: Tracer kinetic models are used in arterial spin labeling (ASL); however, deciding which model parameters to fix or fit is not always trivial. The identifiability of the resultant system of equations is useful to consider, since it will likely impact parameter uncertainty. Here, we analyze the identifiability of two-compartment models used in multi-echo (ME) blood-brain-barrier (BBB)-ASL and evaluate the reliability of the fitted water-transfer rate ).
View Article and Find Full Text PDF