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Optimizing global connectivity in spatial networks, either through rewiring or adding edges, can increase the flow of information and increase the resilience of the network to failures. Yet, rewiring is not feasible for systems with fixed edges and optimizing global connectivity may not result in optimal local connectivity in systems where that is wanted. We describe the local network connectivity optimization problem, where costly edges are added to a systems with an established and fixed edge network to increase connectivity to a specific location, such as in transportation and telecommunication systems. Solutions to this problem maximize the number of nodes within a given distance to a focal node in the network while they minimize the number and length of additional connections. We compare several heuristics applied to random networks, including two novel planar random networks that are useful for spatial network simulation research, a real-world transportation case study, and a set of real-world social network data. Across network types, significant variation between nodal characteristics and the optimal connections was observed. The characteristics along with the computational costs of the search for optimal solutions highlights the need of prescribing effective heuristics. We offer a novel formulation of the genetic algorithm, which outperforms existing techniques. We describe how this heuristic can be applied to other combinatorial and dynamic problems.
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http://dx.doi.org/10.7717/peerj-cs.605 | DOI Listing |
Glob Chang Biol
September 2025
Chair of Silviculture, Faculty of Environment and Natural Resources, Institute of Forest Sciences, University of Freiburg, Freiburg, Germany.
Mixed-species forests are proposed to enhance tree resistance and resilience to drought. However, growing evidence shows that tree species richness does not consistently improve tree growth responses to drought. The underlying mechanisms remain uncertain, especially under unprecedented multiyear droughts.
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Thoracic Surgery, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, China.
Background: Lung cancer remains the leading cause of cancer-related mortality globally, primarily due to late-stage diagnosis, molecular heterogeneity, and therapy resistance. Key biomarkers such as EGFR, ALK, KRAS, and PD-1 have revolutionized precision oncology; however, comprehensive structural and clinical validation of these targets is crucial to enhance therapeutic efficacy.
Methods: Protein sequences for EGFR, ALK, KRAS, and PD-1 were retrieved from UniProt and modeled using SWISS-MODEL to generate high-confidence 3D structures.
Front Nutr
August 2025
Nutrition Unit, National Agency for Food and Drug Administration and Control, Lagos, Nigeria.
Background: Food labelling policy has become increasingly important in public health due to the rising burden of diet-related diseases. This study examines the compliance of pre-packaged foods sold in Nigerian markets with national food labelling guidelines.
Methods: A total of 883 pre-packaged foods from broad categories were purposively enlisted from selected Nigerian stores and supermarkets.
J Phys Chem C Nanomater Interfaces
September 2025
Institute of Inorganic Chemistry of the Czech Academy of Sciences, Husinec-Řež 1001, 250 68 Řež, Czech Republic.
Coordination polymers (CPs) are versatile materials formed by metal ions and organic ligands, offering a broad range of structural and functional possibilities. Phosphonates and phosphinates are particularly attractive ligands for CPs due to their multiple binding sites, varied coordination geometries, and ability to form robust network structures. Phosphonates, considered harder ligands, form strong bonds with hard metals such as Fe, while phosphinates offer additional versatility due to the varied pendant groups on phosphorus.
View Article and Find Full Text PDFFront Genet
August 2025
Hunan Provincial Key Laboratory of Finance and Economics Big Data Science and Technology, Hunan University of Finance and Economics, Changsha, China.
RNA N4-acetylcytidine (ac4C) is a crucial chemical modification involved in various biological processes, influencing RNA properties and functions. Accurate prediction of RNA ac4C sites is essential for understanding the roles of RNA molecules in gene expression and cellular regulation. While existing methods have made progress in ac4C site prediction, they still struggle with limited accuracy and generalization.
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