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Article Abstract
Background: Glucometers are widely used in animal research due to simplicity and ease of utilization, but their accuracy in blood glucose assessment for hyperlipidemic mice is unknown.
Methods: Here, we compared blood glucose levels measured by a glucometer with plasma glucose levels measured by a standard enzymatic assay for 325 genetically diverse F2 mice derived from LP and BALB/c (BALB) Apoe mice. Non-fasting glucose levels were measured before initiation of a Western diet and after 11 weeks on the diet.
Results: On chow diet, lab-measured plasma glucose levels were 279.5 ± 42.6 mg/dl (mean ± SD), while blood glucose values measured by glucometer were 138.7 ± 16.6 mg/dl. The two measures had no correlation (R = 0.006, p = 0.167). On the Western diet, plasma glucose levels rose to 351.1 ± 121.6 mg/dl, while glucometer-measured blood glucose fell to 128.7 ± 27.9 mg/dl. The two measures showed a moderate correlation (R = 0.111, p = 3.1E-9). Lab-measured plasma glucose showed strong positive correlations with plasma triglyceride and non-high-density lipoprotein cholesterol levels, while glucometer-measured blood glucose showed an inverse correlation with non-high-density lipoprotein levels on the chow diet.
Conclusions: Our results indicate that hyperlipidemia affects the accuracy of glucometers in measuring blood glucose levels of mice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478864 | PMC |
| http://dx.doi.org/10.1016/j.amjms.2021.06.014 | DOI Listing |
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